Pneumatosis Intestinalis and Portal Venous Gas Without Bowel Ischemia in a Patient Treated with Irinotecan and Cisplatin

Kung, David; Ruan, Daniel T.; Chan, Rodney K.; Ericsson, M.; Saund, Mandeep S.

doi:10.1007/s10620-007-9846-9

Cited by 34 publications

(21 citation statements)

References 18 publications

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“…In addition, no causes of HPVG (including metastatic sites) were detected with the colonoscopy that was performed afterward. There are a couple of reports of HPVG as a complication of anticancer chemotherapy [7][8][9]. Although the authors failed to elucidate the mechanism of HPVG in their case, the damage to intestinal mucosa and increased mucosal permeability associated with chemotherapy agents cannot be completely ruled out as the cause in our case.…”

Section: Discussionmentioning

confidence: 69%

Hepatic portal venous gas in a patient undergoing chemotherapy for non-small cell lung cancer

et al. 2012

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A 71-year-old man was diagnosed with c-stage IV non-small cell lung cancer and treated with anticancer chemotherapy. On the 29th day of chemotherapy, the patient had slight upper abdominal fullness and pain. Ultrasonography showed gas flow in the portal vein and computed tomography confirmed the presence of gas in the peripheral lesion of the liver. We made a diagnosis of hepatic portal venous gas. He was successfully treated with conservative management. No mechanical or bacterial factors were identified, and the occurrence of HPVG in our case was considered to be related to his cancer-bearing condition and the chemotherapy agents. Although HPVG during chemotherapy is extremely rare, we should be aware of this complication in patients undergoing chemotherapy.

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Section: Discussionmentioning

confidence: 69%

Hepatic portal venous gas in a patient undergoing chemotherapy for non-small cell lung cancer

et al. 2012

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“…To our knowledge, FU-related or FU-induced PCI has not been reported previously. This case will add to the reported series of patients with FU-induced small bowel toxicity [3,4] and chemotherapy-related PCI [5][6][7][8][9] .…”

Section: Introductionmentioning

confidence: 81%

“…Several chemotherapeutic agents have been reported to be associated with PCI, including cyclophosphamide, cytarabine, vincristine, doxorubicin, daunorubicin, etoposide, docetaxel, irinotecan and cisplatin [5][6][7][8][9] . Although fluorouracil-related PCI has not been previously described, the cytotoxic effect of chemotherapy on the epithelial bowel can also play a role in the pathogenesis of PCI [7] .…”

Section: Discussionmentioning

confidence: 99%

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Pneumatosis cystoides intestinalis after fluorouracil chemotherapy for rectal cancer

Mimatsu¹,

Oida²,

Kawasaki³

et al. 2008

WJG

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Pneumatosis cystoides intestinalis (PCI) is a relatively rare condition characterized by intraluminal gas in the gastrointestinal tract. Several chemotherapeutic agents have been reported to be associated with PCI, although fluorouracil-related PCI is extremely rare. We report a case of a 76-year old man who received adjuvant chemotherapy for rectal cancer with fluorouracil (FU) and leucovorin (LV). After 1 cycle of the treatment, he presented with diarrhea and abdominal pain. Abdominal radiogram revealed the presence of free air under the diaphragm and intramural gas in the intestine. Laparotomy was p e r fo r m e d , s h o w i n g a s u s p e c t e d d i a g n o s i s o f perforation in the gastrointestinal tract. Intraoperative findings revealed pneumatosis of the intestine without evidence of perforation. He was treated supportively and his symptoms improved. In conclusion, we should consider the possibility of PCI occurring in patients with malignancies during chemotherapy treatment.

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“…The mortality rate is high when HPVG is caused by bowel necrosis; in such cases, emergency surgery is required [2]. HPVG has rarely been reported in patients undergoing chemotherapy [3,4,5,6,7]. For the first time to our knowledge, we report a case of HPVG in a patient who received chemotherapy with pemetrexed and carboplatin for lung cancer.…”

Section: Introductionmentioning

confidence: 99%

A Case of Hepatic Portal Venous Gas in a Patient Treated with Pemetrexed and Carboplatin for Lung Cancer

Kanagushi¹,

Fujita

Hanaoka

et al. 2014

Chemotherapy

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Hepatic portal venous gas (HPVG) has rarely been reported in patients undergoing chemotherapy. We encountered a case of a 64-year-old man with stage IIIA lung adenocarcinoma who received adjuvant chemotherapy with pemetrexed and carboplatin and developed HPVG 1 day after the second chemotherapy. An emergency operation was performed, but the patient died 2 days after the operation because of multiple organ failure caused by sepsis. Since the patient had complained of alternating abdominal bloating and diarrhea during chemotherapy, we considered that the cause of HPVG was intestinal mucosal disruption and increased intraluminal pressure due to the chemotherapy.

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Pneumatosis Intestinalis and Portal Venous Gas Without Bowel Ischemia in a Patient Treated with Irinotecan and Cisplatin

Cited by 34 publications

References 18 publications

Hepatic portal venous gas in a patient undergoing chemotherapy for non-small cell lung cancer

Hepatic portal venous gas in a patient undergoing chemotherapy for non-small cell lung cancer

Pneumatosis cystoides intestinalis after fluorouracil chemotherapy for rectal cancer

A Case of Hepatic Portal Venous Gas in a Patient Treated with Pemetrexed and Carboplatin for Lung Cancer

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