Pneumococcal and influenza vaccination status of hospitalized adults with community acquired pneumonia and the effects of vaccination on clinical presentation

Cetinoglu, Ezgi Demirdogen; Uzaslan, Esra; Sayıner, Abdullah; Çilli, Aykut; Kılınç, Oğuz; Coşkun, Ayşın Şakar; Hazar, Armagan; Köktürk, Nurdan; Filiz, Ayten; Polatlı, Mehmet

doi:10.1080/21645515.2017.1339851

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…The occurrence of respiratory failure was higher among unvaccinated subjects, although this difference was not significant statistically. Similar results have been noted by other investigators also [ 21 ], where significant differences were observed between groups in age, some symptoms and radiological findings. Although there is no strong association between the radiographic patterns and the causative agents, consolidation is more frequently observed in pneumococcal pneumonia.…”

Section: Discussionsupporting

confidence: 92%

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

et al. 2023

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BackgroundInfectious exacerbations are crucial events that dictate the natural course of COPD patients. Pneumococcal vaccination has shown to decrease incidence of community acquired pneumonia in COPD patients. There is paucity of data on outcomes of hospitalisation in pneumococcal vaccinated COPD patients in comparison with unvaccinated subjects.ObjectivesTo evaluate the difference in hospitalisation outcomes in pneumococcal vaccinatedversusunvaccinated COPD subjects hospitalized with Acute Exacerbation.MethodsThis was a prospective analytical study on 120 subjects hospitalised with acute COPD exacerbation. 60 patients with prior pneumococcal vaccination and 60 unvaccinated patients were recruited. Outcomes of hospitalisation like mortality rate, need for assisted ventilation, length of hospital stay, need for ICU care, and length of ICU stay were collected and compared between two groups with appropriate statistical tools.Results60% of unvaccinated patients (36/60) required assisted ventilation whereas only 43.3% of vaccinated subjects (26/60) needed assisted ventilation (p value 0.04). Most of the secondary outcomes were better in the vaccinated group. The mean length of ICU stay in the vaccinated group was 0.67 days (±1.11) compared to 1.77 (± 1.89) in the unvaccinated group. The mean length of hospital stay was 4.50 days (±1.64) and 5.47 days (±2.03) days in vaccinated and unvaccinated group respectively (p value 0.005).ConclusionsCOPD patients who have received prior pneumococcal vaccination have better outcomes when they are hospitalised for an acute exacerbation. Pneumococcal vaccination may be recommended for all patients with COPD who are at risk of hospitalisation with acute exacerbation.

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Section: Discussionsupporting

confidence: 92%

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

et al. 2023

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“…It was concluded that previous vaccination did not seem to significantly affect the clinical outcomes. 37 In our study, 8% patients had both vaccines, history of hospitalization in the last year, reasons for hospitalization, and even infection were not found to be related with vaccination. We assume that the reason for the lack of relationship between hospitalization for infection and vaccination could be linked to the fact that besides the low number of patients, the etiologic agents were heterogeneous.…”

Section: Discussionmentioning

confidence: 43%

Influenza and pneumonia vaccination rates in patients hospitalized with acute respiratory failure

Candemir¹,

Turk²,

Ergün³

et al. 2019

Human Vaccines & Immunotherapeutics

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Background and method: Despite their proven effect, the rates of vaccinations are low. The aim of this study was to determine the rates and associated factors of influenza and pneumonia vaccinations in patients who were hospitalized because of acute respiratory failure. Patients hospitalized because of acute hypoxemic or hypercapnic respiratory failure were recruited for this retrospective study. A survey was conducted with 97 patients. Primary diagnoses, ages, reasons of hospitalizations, education status, vaccination rates, information resources, and thoughts about vaccinations were recorded. Results: In total 45 (46%) of the patients were female, and 52 (54%) were male. The mean age was 67 ± 12 years. The primary diagnoses were lung disorders (n = 77, 79%), cardiac disorders (n = 16, 17%), and neuromuscular disorders (n = 5, 4%). In total 72 (74%) patients had chronic obstructive pulmonary disease (COPD) with primary lung disorders. All patients were hospitalized due to acute respiratory failure. The main reason for acute respiratory failure was infection in 40 patients (42%). The overall influenza and pneumococcal vaccination rates were 26% and 15%, respectively; for patients with COPD it was 30% and 17%, respectively. The main providers of information were doctors (42%). Vaccination status was not associated with infections or other reasons of hospitalization, age, sex, educational status, and number of hospital admissions in the previous year. A total of 51 patients (52%) had no belief in the benefits of vaccinations. Conclusion: Vaccination rates were found to be low in patients who were frequently hospitalized. Vaccination status was not related with hospitalization due to infections and history of hospitalization; awareness of vaccinations should be improved both in doctors and patients.

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“…However, Demirdogen Cetinoglu et al showed that influenza vaccination did not affect the clinical outcome of hospitalized adult CAP patients. This result may be related to the low influenza vaccination rate in the elderly [23]. Therefore, further research is needed to analyze this in the future.…”

Section: Discussionmentioning

confidence: 99%

Association of Consecutive Influenza Vaccinations and Pneumonia: A Population-Based Case-Control Study

Yeh

Chan

Yang

et al. 2019

IJERPH

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The purpose of this study was to investigate whether individuals receiving influenza vaccines have a lower risk of pneumonia. A nationwide population-based case-control study was conducted using data from the National Health Insurance Research Database in Taiwan. We enrolled 7565 patients each in pneumonia and non-pneumonia groups after diagnosis of patients with chronic pulmonary disease, and these patients were individually age and sex matched in a 1:1 ratio. Using conditional logistic regression analysis, adjusted odds ratios (aORs) were estimated in patients who received influenza vaccination and those who had not previously had pneumonia. Moreover, we also analyzed the interval between vaccination and the onset of pneumonia and the number of vaccinations received by patients. This was compared with patients who never received influenza vaccination. Patients who had received influenza vaccination and had been vaccinated for two consecutive years (aOR = 0.85, confidence interval (CI) = 0.79–0.93 and aOR = 0.75, CI = 0.67–0.85, respectively) showed lower rates of pneumonia occurrence by 15–25%. In conclusion, influenza vaccination significantly reduces the occurrence of pneumonia, especially in individuals who receive vaccination in consecutive years.

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Pneumococcal and influenza vaccination status of hospitalized adults with community acquired pneumonia and the effects of vaccination on clinical presentation

Abstract: This study showed that, among patients hospitalized with CAP, the FV and/or PV rates are low. Prior vaccination does not appear to significantly affect the clinical outcomes.

Cited by 16 publications

References 43 publications

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

Hospitalisation outcomes in pneumococcal-vaccinatedversus-unvaccinated patients with exacerbation of COPD: results from the HOPE COPD Study

Influenza and pneumonia vaccination rates in patients hospitalized with acute respiratory failure

Association of Consecutive Influenza Vaccinations and Pneumonia: A Population-Based Case-Control Study

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