Pneumococcal Biofilms and Their Intervention Strategies

Rahaman, Lovely; Ghosh, Shreya; Nath, Nandita; Sharma, Bipin Kumar

doi:10.22159/ijpps.2018v10i3.23254

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…14 The overall population must be appropriately told and mindfulness must be made with respect to the perils word related residue can incite in invulnerable traded off or geriatric and paediatric populaces whose resistance system isn't sufficiently capable to stop the section of the pathogen. 15 Legitimate safeguards must be taken so as to decrease the event of the equivalent. 16…”

Section: Discussionmentioning

confidence: 99%

Cotton Dust Induced Pneumonia in Geriatric Patients in Kongu Nadu Region: A Case History

Andhuvan¹,

Bhavani²,

Khatija³

et al. 2019

JYP

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Ceaseless introduction to cotton residue may result in different respiratory disorders like pneumonia, Acquired Respiratory Distress Syndrome (ARDS) and so on. Such occupation initiated disarranges are in the ascent right now. Here is an instance of a 70-year-old male patient who is experiencing network procured pneumonia brought about by presentation to cotton dust gained because of working at a material industry. The essential causative living being for the equivalent was observed to be Acinetobacter and E. coli. He is known to have no co-morbidities on affirmation and has boss grumblings of hack with expectoration, blood-decoloured sputum, fever and shortness of breath for around about fourteen days. The patient was found in a condition of respiratory trouble amid confirmation, which was basically treated with Non-Invasive Ventilation. The patient was observed to be unreasonably hypoxic because of declining ARDS. The patient's chest x-beam uncovered combination and the patient were at first treated with anti-toxins and given noradrenaline for hemodynamic help. Antimicrobial treatment included Colistin and Cotrimoxazole. The patient additionally hinted at different organ harm, in particular hinted at Acute Kidney Damage. The condition was recognized because of anomalous creatinine levels or pee yield. Steps were taken to control and treat the equivalent.

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Section: Discussionmentioning

confidence: 99%

Cotton Dust Induced Pneumonia in Geriatric Patients in Kongu Nadu Region: A Case History

Andhuvan¹,

Bhavani²,

Khatija³

et al. 2019

JYP

View full text Add to dashboard Cite

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Isolation and characterization of novel phage (Podoviridae ɸParuNE1) and its efficacy against multi-drug-resistant Pseudomonas aeruginosa planktonic cells and biofilm

Enwuru

Gill

Anttonen

et al. 2021

Beni-Suef Univ J Basic Appl Sci

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Background Bacterial pathogen (Pseudomonas aeruginosa) could form biofilm that conveys multi-drug resistance. Bacteriophage as an alternative to antibacterial resistance is useful against biofilm complications. This study evaluated antibacterial and biofilm removal activities of lytic phage, specific against multi-drug-resistant clinical P. aeruginosa. Results The phage showed a wide range of pH (5–10) and heat (7–44 °C) stability. Electron microscopy showed ɸPauNE1 phage head (60 nm in diameter) and non-contractile tail (12 nm in length by 8 nm in width); hence, the family Podoviridae and the order Caudovirales. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) showed structured protein of 55 kDa and double-stranded DNA of 45 kb. The phage was species specific and had broad host range activity. It inhibited bacterial growth at multiplicity of infection (MOI) 1–0.000001 pfu/ml. Inhibition was maximal at both low (1 × 105) and high (1 × 109) bacterial CFU/ml. Biofilm removal test showed that the phage removed more than 60% cell biomass within CFU/ml of 1.5 × 108, 6.0 × 108 and l.0 × 109. Conclusion Phage (ɸPauNE1) was unique and had broad host range activity. The phage exhibited strong bacteriolytic activity against biofilm forming multi-drug-resistant strains. It had no lytic effect on the heterogeneous strains and so a promising bioagent.

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Pneumococcal Biofilms and Their Intervention Strategies

Cited by 2 publications

References 35 publications

Cotton Dust Induced Pneumonia in Geriatric Patients in Kongu Nadu Region: A Case History

Cotton Dust Induced Pneumonia in Geriatric Patients in Kongu Nadu Region: A Case History

Isolation and characterization of novel phage (Podoviridae ɸParuNE1) and its efficacy against multi-drug-resistant Pseudomonas aeruginosa planktonic cells and biofilm

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