Pneumococcal meningitis: An evaluation of prognostic factors in 164 cases based on mortality and on a study of lasting sequelae

Cognitive outcome in adults with moderate disability after pneumococcal meningitis

“…The dynamic character of sequelae in survivors of bacterial meningitis has been described previously and implies that time since illness is an important factor in follow-up studies of adults after pneumococcal meningitis. 14,17 Our finding is in agreement with results of a prospective longitudinal cohort study on long-term cognitive functioning in children after bacterial meningitis. 18 This study showed a significant 'catch-up' of children with cognitive impairment after meningitis in executive function and cognitive speed, which is largely comparable with our results.…”

“…Other studies on cognitive impairment among adults after bacterial meningitis described cognitive slowness, impairment of psychomotor performance, reduction in visuoconstructive performance and higher scores on depression scales. 5,[13][14][15][16] In a previous study we found that even adults with good recovery after pneumococcal meningitis are at significant risk for cognitive slowness. 5 In this study, 51 patients with good recovery after meningococcal and pneumococcal meningitis were examined.…”

“…The association between the severity of neurological sequelae after pneumococcal meningitis and neuropsychological abnormalities is weak. 14 Since the categories of the GOS are very broad, the GOS seems to be less adequate as an instrument to evaluate cognitive outcome after adulthood pneumococcal meningitis. Classification of patients based on the nature of their neurological sequelae, such as cranial-nerve palsies vs. cerebral focal abnormalities may be more useful to identify patients who are at risk for cognitive impairments.…”

Assessing the Chronic Neuropsychologic Sequelae of Human Immunodeficiency Virus–Negative Cryptococcal Meningitis by Using Diffusion Tensor Imaging

“…27 Cognitive deficiencies after bacterial and viral meningitis (predominantly shortterm and working memory) also have been described. 28 Although impaired cognition related to CM infection, ranging from acute confusion, psychosis, and mania to encephalopathy, is well known, evidence is based on case reports [29][30][31][32] or comorbidity with HIV infection.…”

Cost-effectiveness of polysaccharide pneumococcal vaccination in people aged 65 and above in Poland

“…47 Elderly patients with PM were considered to have a 33% probability of developing long-term sequelae severe enough to affect their daily life and ability to work. 48 Due to lack of evidence, mortality rates for individuals developing long-term sequelae were conservatively assumed to be the identical to those observed in the general population.…”