Pneumocystis carinii isolated from lung lavage fluid in an infant with cystic fibrosis

Royce, Fred H.; Blumberg, Dean A.

doi:10.1002/(sici)1099-0496(200003)29:3<235::aid-ppul12>3.0.co;2-9

Cited by 9 publications

(9 citation statements)

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“…Several works support a significant association of P. jirovecii colonization with diverse chronic pulmonary diseases (6,12,21). Few severe PcP cases in cystic fibrosis (CF) patients have been reported (23,25), and only some studies have reported Pneumocystis carriage, the clinical significance of which remains practically unexplored (14,(18)(19)(20)(22)(23)(24)(25)(26). The aims of the present study were therefore to evaluate the prevalence of P. jirovecii colonization during a prospective multicenter observational study, to provide information regarding the distribution of Pneumocystis genotypes, and to explore the clinical relevance of Pneumocystis colonization among CF patients in France.…”

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confidence: 95%

“…Three studies have reported the association of P. jirovecii and P. aeruginosa in CF patients (14,22,25), but whether Pneumocystis infection/colonization complicated CF-associated lung disease remains unclear. In fact, little is known regarding the in vivo interactions between species, especially considering the bacterial and fungal community as a unique entity (lung microbiota) (8,11,31).…”

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confidence: 99%

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Prospective Multicenter Study of Pneumocystis jirovecii Colonization among Cystic Fibrosis Patients in France

et al. 2012

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Prospective Multicenter Study of Pneumocystis jirovecii Colonization among Cystic Fibrosis Patients in France

et al. 2012

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“…A previous study of CF patients from Spain did not identify the pathogen by conventional staining methods [11]. P. jirovecii has been identified by nested PCR in the respiratory tract of CF patients [2,12,13], but much remains unknown with respect to the molecular epidemiology of P. jirovecii infection among CF patients. The aim of the present study was to perform a wide epidemiological analysis in order to provide information regarding the prevalence of colonisation and distribution of P. jirovecii genotypes among CF patients from Spain.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of colonisation and genotypic characterisation of Pneumocystis jirovecii among cystic fibrosis patients in Spain

Respaldiza

Montes-Cano

Dapena

et al. 2005

Clinical Microbiology and Infection

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Pneumocystis jirovecii colonisation may occur among cystic fibrosis (CF) patients because of their underlying pulmonary disease. A wide epidemiological analysis was performed among CF patients from Spain to assess the prevalence of P. jirovecii colonisation and the distribution of different genotypes. P. jirovecii was identified by nested PCR targeting the mitochondrial large-subunit rRNA gene from sputum samples or oropharyngeal washes. The genotype was determined by direct sequencing. The prevalence of P. jirovecii colonisation among 88 consecutive CF patients was 21.5%. The polymorphisms identified were 85C/248C (45.4%), 85T/248C (27.2%) and 85A/248C (18.1%); in one case, a mix of genotypes was found. Colonisation was more frequent in subjects aged < 18 years (25.5% vs. 15.1%). Among the patients studied, 20.8% received treatment with azithromycin; all of these patients were colonised with P. jirovecii, but none developed Pneumocystis pneumonia (PcP) during a 1-year follow-up period. Concordance in the colonisation status of siblings suggested a common source of infection or person-to-person transmission.

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“…BAL examination revealed P. jirovecii asci and pathogens usually associated with CF, such as S. aureus and P. aeruginosa . The patient recovered after cotrimoxazole treatment (Royce and Blumberg, 2000 ). The second one concerned a 16-week old HIV-seronegative infant newly diagnosed with CF who underwent a BAL to investigate chronic cough etiology.…”

Section: Pulmonary Colonization With P Jirovecii mentioning

confidence: 99%

“…Further studies provided additional data in this field (Respaldiza et al, 2005 ; Le Gal et al, 2010 ; Hernandez-Hernandez et al, 2012 ; Pederiva et al, 2012 ; Green et al, 2016 ; Nevez et al, 2018 ). Moreover, PCP can also occur in CF patients (Royce and Blumberg, 2000 ; Quattrucci et al, 2005 ; Solé et al, 2006 ; Kaur et al, 2016 ; Wojarski et al, 2018 ). The objective of this review is to compile available information on P. jirovecii and CF worldwide.…”

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confidence: 99%

Pneumocystis jirovecii in Patients With Cystic Fibrosis: A Review

Bonnet

Gal

Calderón

et al. 2020

Front. Cell. Infect. Microbiol.

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Pneumocystis pneumonia (PCP) remains the most frequent AIDS-defining illness in developed countries. This infection also occurs in non-AIDS immunosuppressed patients, e.g., those who have undergone an organ transplantation. Moreover, mild Pneumocystis jirovecii infections related to low pulmonary fungal burden, frequently designated as pulmonary colonization, occurs in patients with chronic pulmonary diseases, e.g., cystic fibrosis (CF). Indeed, this autosomal recessive disorder alters mucociliary clearance leading to bacterial and fungal colonization of the airways. This mini-review compiles and discusses available information on P. jirovecii and CF. It highlights significant differences in the prevalence of P. jirovecii pulmonary colonization in European and Brazilian CF patients. It also describes the microbiota associated with P. jirovecii in CF patients colonized by P. jirovecii. Furthermore, we have described P. jirovecii genomic diversity in colonized CF patients. In addition of pulmonary colonization, it appears that PCP can occur in CF patients specifically after lung transplantation, thus requiring preventive strategies. In other respects, Pneumocystis primary infection is a worldwide phenomenon occurring in non-immunosuppressed infants within their first months. The primary infection is mostly asymptomatic but it can also present as a benign self-limiting infection. It probably occurs in the same manner in CF infants. Nonetheless, two cases of severe Pneumocystis primary infection mimicking PCP in CF infants have been reported, the genetic disease appearing in these circumstances as a risk factor of PCP while the host-pathogen interaction in older children and adults with pulmonary colonization remains to be clarified.

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Pneumocystis carinii isolated from lung lavage fluid in an infant with cystic fibrosis

Cited by 9 publications

References 9 publications

Prospective Multicenter Study of Pneumocystis jirovecii Colonization among Cystic Fibrosis Patients in France

Prospective Multicenter Study of Pneumocystis jirovecii Colonization among Cystic Fibrosis Patients in France

Prevalence of colonisation and genotypic characterisation of Pneumocystis jirovecii among cystic fibrosis patients in Spain

Pneumocystis jirovecii in Patients With Cystic Fibrosis: A Review

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