Pneumocystis diversity as a phylogeographic tool

Derouiche, Sandra; Deville, Manjula; Taylor, M. Joan; Akbar, Haroon; Guillot, Jacques; Carreto-Binaghi, LE; Pottier, Muriel; Aliouat, EM; Aliouat-Denis, Cécile-Marie; Dei‐Cas, Eduardo; Demanche, Christine

doi:10.1590/s0074-02762009000100017

Cited by 13 publications

(17 citation statements)

References 34 publications

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“…A comprehensive phylogeny of Pneumocystis from bats is in progress, and comparison with bat phylogeny suggests coevolution (C. Demanche and C.-M. Aliouat-Denis, unpublished results) as it was reported in primates (27,41,46) and suggested in other mammalian groups (41). Finally, the link between genetic variability of Pneumocystis isolated from populations of the same bat species and their geographic localization could be exploited in terms of phylogeographical research (31).…”

Section: Discussionmentioning

confidence: 83%

“…Interestingly, Pneumocystis polymorphism seemed to be related with T. brasiliensis subspecies, which have been described on the basis of geographical distribution and morphology (81). As we have previously suggested (31), Pneumocystis strain polymorphism could be used as a phylogeographic tool to be applied to host natural populations.…”

Section: Discussionmentioning

confidence: 99%

“…2). In contrast, Glossophaga soricina and Tadarida brasiliensis species each harbored 2 variants of Pneumocystis mtLSU rDNA depending on the collection area (31). The mtLSU rDNA sequences of Pneumocystis detected in G. soricina from French Guyana and Mexico diverged by 0.35%, corresponding to one nucleotide difference (Table 9), and grouped together on a phenetic branch that is supported by a 100% bootstrap value (Fig.…”

Section: Detection Ofmentioning

confidence: 90%

“…Indeed, the narrow host specificity of Pneumocystis species emerged clearly from the failure of cross species infection among laboratory animals (1,38) or between humans and SCID mice (33). Surveys in domestic, synanthropic, or wild species showed that mammals may harbor one or several host-specific Pneumocystis species or strains (3,17,27,31,41,46).…”

mentioning

confidence: 99%

“…However, ultrastructure (25,99), short-term culture (2,19), and cell sorting approaches (56,57) led to quite heuristic life cycle hypotheses. Furthermore, using PcP animal models, molecular strategies and the exploring of Pneumocystis occurrence in wild mammals resulted in major advancements, like the notions of strong host species specificity (1,27,31,33,38,41) and coevolution (3,27,31,46). Bats (Chiroptera) are widely distributed across various ecosystems and constitute one of the largest groups of mammals, second in number of species after the order Rodentia and first in number of individuals (69).…”

mentioning

confidence: 99%

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Characterizing Pneumocystis in the Lungs of Bats: Understanding Pneumocystis Evolution and the Spread of Pneumocystis Organisms in Mammal Populations

Akbar

Pinçon

Aliouat-Denis

et al. 2012

Appl Environ Microbiol

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Bats belong to a wide variety of species and occupy diversified habitats, from cities to the countryside. Their different diets (i.e., nectarivore, frugivore, insectivore, hematophage) lead Chiroptera to colonize a range of ecological niches. These flying mammals exert an undisputable impact on both ecosystems and circulation of pathogens that they harbor. Pneumocystis species are recognized as major opportunistic fungal pathogens which cause life-threatening pneumonia in severely immunocompromised or weakened mammals. Pneumocystis consists of a heterogeneous group of highly adapted host-specific fungal parasites that colonize a wide range of mammalian hosts. In the present study, 216 lungs of 19 bat species, sampled from diverse biotopes in the New and Old Worlds, were examined. Each bat species may be harboring a specific Pneumocystis species. We report 32.9% of Pneumocystis carriage in wild bats (41.9% in Microchiroptera). Ecological and behavioral factors (elevation, crowding, migration) seemed to influence the Pneumocystis carriage. This study suggests that Pneumocystis-host association may yield much information on Pneumocystis transmission, phylogeny, and biology in mammals. Moreover, the link between genetic variability of Pneumocystis isolated from populations of the same bat species and their geographic area could be exploited in terms of phylogeography.

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