Pneumocystis jiroveci Pneumonia (PJP) in a Renal Transplant Patient: Diagnostic and Management Difficulties

Vakil, Abhay; Okhotin, Helena; Upadhyay, Hineshkumar; Sherani, Khalid; Cervellione, Kelly; Fein, Alan M.

doi:10.1378/chest.1691079

Cited by 1 publication

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“…The most frequent cases of PCP have been observed among patients with AIDS, although other individuals with immunosuppr-ession are also at risk of this infection. Different types of malignancies, congenital immune deficiency [ 9 ], diabetes [ 7 ], organ transplantation; malnutrition [ 3 , 32 - 23 ] and immunosuppressive drugs [ 5 , 20 , 34 ] are the main predisposing factors for PCP.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of Pneumocystis jirovecii using polymerase chain reaction in immunocompromised patients with pulmonary disorders in northeast of Iran

et al. 2015

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Background and Purpose:Pneumocystis pneumonia, caused by Pneumocystis jirovecii, is a fatal disease threatening patients with AIDS or immunosuppression. Assessment of colonization in these patients is of great significance, since it can lead to severe pulmonary disorders. Considering the scarcity of published reports on Pneumocystis jirovecii isolates from patients in Mashhad, Iran, we aimed to evaluate pneumocystis colonization in individuals with different pulmonary disorders.Materials and Methods:We used nested polymerase chain reaction (PCR) method to amplify mitochondrial large subunit-ribosomal ribonucleic acid (mtLSU-rRNA) gene in 60 bronchoalveolar lavage (BAL) samples, obtained from patients, referring to the Department of Internal Medicine (Pulmonary Diseases Section) at Imam Reza Hospital, affiliated to Mashhad University of Medical Sciences, Mashhad, Iran. Results:DNA of Pneumocystis jirovecii was detected in 10 out of 60 BAL samples (16.66%) via nested PCR method.Conclusion:According to the present findings, the colonization rate of Pneumocystis jirovecii was similar to the rates reported in other similar studies in Iran.

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