Pneumonectomy due to lung cancer results in a more pronounced activation of coagulation system than lobectomy

Świniarska, Joanna; Żekanowska, Ewa; Dancewicz, Maciej; Bella, Mariusz; Szczęsny, Tomasz Jarosław; Kowalewski, Janusz

doi:10.1016/j.ejcts.2009.04.070

Cited by 16 publications

(8 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We identified several patient-specific risk factors including older age and obesity as independent predictors of postdischarge VTE, consistent with other single-institution series [1,6,24]. Previous data have also established the causal relationship between performance of pneumonectomy and risk for VTE [16,25,26]. These conclusions are consistent with our analysis; however this manuscript is the first to identify the association between pneumonectomy and VTE risk in the postdischarge period, based on our review of the current literature.…”

Section: Commentsupporting

confidence: 89%

Timing and Risk Factors Associated With Venous Thromboembolism After Lung Cancer Resection

Thomas

Arnold

Hoag³

et al. 2018

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

Significant proportions of VTE events occur after hospital discharge. Although there are data to suggest that the risk for VTE extends beyond this period, few patients are managed with postdischarge prophylaxis. These data suggest that postdischarge prophylaxis should be considered for those patients at high risk for VTE, particularly for older patients, those who are obese, and after extended or lengthy resections.

show abstract

Section: Commentsupporting

confidence: 89%

Timing and Risk Factors Associated With Venous Thromboembolism After Lung Cancer Resection

Thomas

Arnold

Hoag³

et al. 2018

The Annals of Thoracic Surgery

View full text Add to dashboard Cite

show abstract

“…The activation state persists during surgery and is independent of the anaesthetic agents used. These results confirm previous studies performed on patients undergoing major abdominal surgery for colon-rectal cancer [ 27 ], hepatic cancer resection [ 28 ], pneumonectomy for lung cancer [ 29 ].…”

Section: Discussionsupporting

confidence: 91%

Perioperative changes in pro and anticoagulant factors in prostate cancer patients undergoing laparoscopic and robotic radical prostatectomy with different anaesthetic techniques

Sofra¹,

Antenucci²,

Gallucci³

et al. 2014

J Exp Clin Cancer Res

View full text Add to dashboard Cite

BackgroundLaparoscopic prostatectomy (LRP) may activate clotting system influencing the risk of perioperative thrombosis in patients with prostate cancer. Moreover, different anaesthetic techniques can also modify coagulant factors. Thus, the aim of this study was to investigate the effects on pro- and anti-coagulant and fibrinolytic factors of two established types of anaesthesia in patients with prostate cancer undergoing elective LRP.Methods102 patients with primary prostate cancer, who underwent conventional LRP or robot-assisted laparoscopic prostatectomy (RALP), were studied and divided into 2 groups to receive total intravenous anesthesia with target-controlled infusion (TIVA-TCI) or balanced inhalation anaesthesia (BAL) prior to surgery. Before the induction of anaesthesia (T0), 1 hr (T1) and 24 hrs post-surgery (T2), some pro-coagulant factors, fibronolysis markers, p-selectin and haemostatic system inhibitors were evaluated.ResultsBoth TIVA-TCI and BAL patients showed a marked and significant increase in pro-coagulant factors and consequent reduction in haemostatic system inhibitors in the early post operative period (p???0.004 for each markers). Use of RALP showed a significant increase in prothrombotic markers as compared to LRP. In TIVA patients undergoing LRP, a significant reduction of p-selectin levels between T0 and T2 (p?=?0.001) was observed as compared to BAL, suggesting a better protective effect on platelet activation of anaesthetic agents used for TIVA.ConclusionsBoth anaesthetic techniques significantly seem to increase the risk of thrombosis in prostate cancer patients undergoing LRP, mainly when the robotic device was utilized, encouraging the use of a peri-operative thromboembolic prophylaxis in these patients.

show abstract

“…One study found that pneumonectomy had a more pronounced activation of coagulation than the lobectomy group on the 7 th postoperative day. 22 We considered that postoperative hypercoagulability on the 7th day could have more confounding factors than that on the 3rd day, such as the infection, on top of the stress of the surgery, but further research is needed to clarify the question.…”

Section: Discussionmentioning

confidence: 99%

Plasma D‐dimer level in the perioperative period in non‐small‐cell lung cancer

Wang¹,

Fu²,

Diao³

et al. 2011

Thoracic Cancer

View full text Add to dashboard Cite

Background: There has been little research on perioperative hypercoagulability in non-small-cell lung cancer patients. The D-dimer can be used to evaluate the hypercoagulability in cancer patients. Methods: Eighty-five non-small-cell lung cancer patients were included in the study. The plasma D-dimer levels during the preoperative and 3rd and 9th day postoperative period were prospectively examined and analyzed along with the clinicopathological characteristics. Results:The medians (interquartile range) of the preoperative, 3rd and 9th day postoperative D-dimer levels were 1.09 (0.77) mg/L, 3.35 (2.31) mg/L and 4.1 (2.55) mg/L respectively (P = 0.00). The preoperative D-dimer level was related with the stage (P = 0.004). The preoperative and the 3rd day postoperative D-dimer levels were both related to patient age (P = 0.014, P = 0.034). The 3rd day postoperative D-dimer levels were arbitrarily stratified into three groups, adenocarcinoma dominated the high and low groups while squamous cell carcinoma dominated the median one (exact P = 0.02). The pneumonectomy group did not show a higher 3rd day postoperative D-dimer level than the lobectomy group (P = 0.064). Conclusion: Non-small-cell lung cancer patients had increasing hypercoagulability within the first 9 postoperative days. Preoperative hypercoagulability was close related with tumor stage. Heterogeneity existed among postoperative hypercoagulability.

show abstract

Pneumonectomy due to lung cancer results in a more pronounced activation of coagulation system than lobectomy

Abstract: Pneumonectomy was associated with significantly higher activation of coagulation system on the seventh postoperative day than lobectomy. TAT complex, TF and E-selectin are promising markers of extensive postoperative activation of coagulation and efficacy of antithrombotic prophylaxis.

Cited by 16 publications

References 24 publications

Timing and Risk Factors Associated With Venous Thromboembolism After Lung Cancer Resection

Timing and Risk Factors Associated With Venous Thromboembolism After Lung Cancer Resection

Perioperative changes in pro and anticoagulant factors in prostate cancer patients undergoing laparoscopic and robotic radical prostatectomy with different anaesthetic techniques

Plasma D‐dimer level in the perioperative period in non‐small‐cell lung cancer

Contact Info

Product

Resources

About