Pneumonia caused by Mycobacterium tuberculosis

Wei, Meili; Zhao, Yan; Qian, Zhuoyu; Yang, Biao; Xi, Jun; Wei, Jun; Tang, Bo

doi:10.1016/j.micinf.2020.05.020

Cited by 50 publications

(38 citation statements)

References 87 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Tuberculosis (TB) is associated with acute pneumonia [ 162 ]. During Mycobacterium (Mtb) infection, M1 macrophages express more P53 than M2 macrophages.…”

Section: Copdmentioning

confidence: 99%

P53 in the impaired lungs

Uddin

Barabutis

2020

DNA Repair

View full text Add to dashboard Cite

Our laboratory is focused on investigating the supportive role of P53 towards the maintenance of lung homeostasis. Acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, pulmonary fibrosis, bronchial asthma, pulmonary arterial hypertension, pneumonia and tuberculosis are respiratory pathologies, associated with dysfunctions of this endothelium defender (P53). Herein we review the evolving role of P53 towards the aforementioned inflammatory disorders, to potentially reveal new therapeutic possibilities in pulmonary disease.

show abstract

“…Tuberculosis (TB) is associated with acute pneumonia [ 162 ]. During Mycobacterium (Mtb) infection, M1 macrophages express more P53 than M2 macrophages.…”

Section: Copdmentioning

confidence: 99%

P53 in the impaired lungs

Uddin

Barabutis

2020

DNA Repair

View full text Add to dashboard Cite

show abstract

“…Tuberculous pneumonia should be taken into consideration as one of the differential diagnoses when a patient presents with pneumonia in high incidence of TB and HIV country [27] , [29] . Acute tuberculous pneumonia is often closely resembled bacterial pneumonia and especially difficult to differentiate from ARF patients with secondary infections, therefore definitive diagnosis might be delayed [30] . Delay in the diagnosis and treatment of tuberculosis patients is still a problem and attributed to both the patient and the health system.…”

Section: Discussionmentioning

confidence: 99%

In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors

Elhidsi

Rasmin

Prasenohadi

2021

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

View full text Add to dashboard Cite

Background/objective Data on acute respiratory failure (ARF) in pulmonary tuberculosis (PTB) patients is limited. This study aims to investigate in-hospital mortality, its clinical risk factors and the accuracy of the existing scoring system in predicting in-hospital mortality. Methods An observational prospective cohort study involving PTB patients with ARF in tertiary hospital, between January 2017 and December 2018, was conducted. The in-hospital mortality was predicted using the National Early Warning Score 2 (NEWS2), quick Sequential Organ Failure Assessment (qSOFA) and CRB-65. Regression models were run to analyze the clinical risk factors for in-hospital Mortality. Sensitivity and specificity of scoring systems were calculated using a Wilson score interval. Results A total of 111 subjects were included. Most of subjects were hypoxemic type respiratory failure (68.5%), advanced lesions (62.2%), new cases (70.3%) and pneumonia co-infection (72.1%) patients. Invasive mechanical ventilation was utilized for 29.73% of cases. There were 53 (47.75%) in-hospital mortality cases and its risk factors were intensive phase treatment (3.34 OR; CI95% 1.27–8.78), P/F ratio < 100 (OR 4.30; CI 95% 1.75–10.59) and renal insufficiency (4.09 OR; CI95% 1.46–11.49). The sensitivity and specificity of NEWS2 ≥ 6, qSOFA ≥ 2 and CRB-65 ≥ 2 were 62.26% and 67.24%; 60.38% and 72.41%; 41.51% and 84.48% respectively. Conclusions Most of PTB with ARF were new cases, advanced lesion and hypoxemic type respiratory failure. Intensive phase treatment, severe hypoxemia and renal insufficiency are independent predictors of in-hospital mortality in PTB patients with ARF. NEWS2, qSOFA and CRB-65 scores were poor to predict the in-hospital mortality.

show abstract

“…Different bacterial strains have been isolated from sputum samples including: Haemophilus influenzae , Klebsiella pneumoniae , Streptococcus pneumoniae , and Moraxella catarrhalis 4 , 5 . The tubercular and the bacterial co-infection can lead to inadequate treatment causing serious complications such as pneumoniae, bronchial anthracofibrosis, and chronic airflow obstruction 5–8 . Unfortunately, many virulent bacterial strains have developed bacterial resistance against most of the currently used antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…Along with the emerged drug resistance, the development of secondary bacterial infection is considered to be a critical problem 4 . Different bacterial strains have been isolated from sputum samples including: Haemophilus influenzae, Klebsiella pneumoniae, Streptococcus pneumoniae, and Moraxella catarrhalis 4,5 . The tubercular and the bacterial co-infection can lead to inadequate treatment causing serious complications such as pneumoniae, bronchial anthracofibrosis, and chronic airflow obstruction [5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%