Pneumonitis Associated With Malaria

Applebaum, Irving L.; Shrager, Joel

doi:10.1001/archinte.1944.00210210002001

Cited by 32 publications

(6 citation statements)

References 3 publications

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“…Instead, it likely reflected a posttreatment inflammatory response with enhanced pulmonary vascular WBC sequestration, causing reduced pulmonary vascular blood volume and reduced pulmonary capillary blood flow after the start of treatment. This finding is supported by our earlier studies, which showed a significant increase in WBC phagocytic activity in patients with uncomplicated malaria within 2 days of the start of treatment [11] and by the few autopsy series that have reported detailed pulmonary intravascular histopathological findings after death from severe malaria [6, 8, 23-27]. Intravascular monocytes are seen to a much greater degree in alveolar capillaries than in other organ microvasculature [6, 8, 24] or peripheral blood [24].…”

Section: Discussionsupporting

confidence: 81%

Lung Injury in Uncomplicated and Severe Falciparum Malaria: A Longitudinal Study in Papua, Indonesia

et al. 2005

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Our results suggest that pulmonary vascular occlusion occurs in both patients with uncomplicated malaria and those with severe malaria, likely from sequestration of both red blood cells (RBCs) and white blood cells. There was also impaired alveolar-capillary membrane function in patients with severe malaria but not in those with uncomplicated malaria. Persistent impairment long after clearance of parasitized RBCs suggests prolonged posttreatment inflammatory alveolar-capillary injury.

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Section: Discussionsupporting

confidence: 81%

Lung Injury in Uncomplicated and Severe Falciparum Malaria: A Longitudinal Study in Papua, Indonesia

et al. 2005

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“…She also reported pulmonary edema in all of her cases, whereas we found it in 20 of 55 CM1-2 (36%). Pneumonia (defined as neutrophils in contiguous alveolar spaces) is a frequent complication in our pediatric population, similar to the pneumonia commonly seen in adults (Applebaum, 1944 ; Spitz, 1946 ; Taylor et al, 2006 ). Spitz found pneumonia in 42%, and we found it in 22% of CM1 and 21% of CM2 cases.…”

Section: Discussionmentioning

confidence: 72%

The systemic pathology of cerebral malaria in African children

Milner

Whitten²,

Kamiza

et al. 2014

Front. Cell. Infect. Microbiol.

119

138

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Pediatric cerebral malaria carries a high mortality rate in sub-Saharan Africa. We present our systematic analysis of the descriptive and quantitative histopathology of all organs sampled from a series of 103 autopsies performed between 1996 and 2010 in Blantyre, Malawi on pediatric cerebral malaria patients and control patients (without coma, or without malaria infection) who were clinically well characterized prior to death. We found brain swelling in all cerebral malaria patients and the majority of controls. The histopathology in patients with sequestration of parasites in the brain demonstrated two patterns: (a) the “classic” appearance (i.e., ring hemorrhages, dense sequestration, and extra-erythrocytic pigment) which was associated with evidence of systemic activation of coagulation and (b) the “sequestration only” appearance associated with shorter duration of illness and higher total burden of parasites in all organs including the spleen. Sequestration of parasites was most intense in the gastrointestinal tract in all parasitemic patients (those with cerebral malarial and those without).

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“…The earlier reports regarding the pulmonary complications of malaria describe a spectrum of respiratory problems ranging from mild bronchitic symptoms to fatal pulmonary apoplexy. 3 Applebaum and Shrager in 1944 4 and Brooks and associates 3 in 1968 recorded a 3 to 10% incidence of pulmonary complications. More recently, a better insight has been gained regarding the spectrum of pulmonary injury, the mechanisms of injury, hemodynamic changes, and the applications of available therapeutic modalities.…”

Section: Pulmonary Complications Of Malaria Vandana Patel Md* Andmentioning

confidence: 97%

“…Pulmonary signs and symptoms develop in 3 to 10% of all patients with falciparum malaria 4 and range from mild cough to fatal adult respiratory distress syndrome. In 12 patients with pulmonary complications resulting from P. falciparum malaria, Punyagupta and colleagues 8 observed the following features: The onset of the pulmonary complications was abrupt.…”

Section: Clinical Presentationmentioning

confidence: 99%