Pneumopathie communautaire fatale à staphylocoque doré sécréteur de la leucocidine de Panton-Valentine

Campion, A.; Cremer, R.; Leteurtre, Stéphane; Fourier, C.; Leclerc, F.

doi:10.1016/s1164-6756(00)80010-9

Cited by 3 publications

(2 citation statements)

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“…We thus hypothesize that the life-threatening hemoptysis in our patients was most likely related to the Panton-Valentine leukocidin produced by the Sa isolates, as in two recent pediatric reports [5,6]. Our patients had diffuse alveolar hemorrhage (DAH), but erosion of larger vessels was also probable.…”

Section: Discussionsupporting

confidence: 57%

“…The clinical course is generally subacute, but the mortality rate is high despite appropriate antibiotic therapy. Hemoptysis is uncommon in adults [3,4] and reports of massive hemoptysis have been described especially in children [5,6,7]. We describe three new consecutive cases of life-threatening hemoptysis in adults with Sa-CAP, discuss the role of Panton-Valentine leukocidin (PVL) and focus on the particular clinical presentation of this new entity recently referred to as "Staphylococcus aureus necrotising pneumonia" [6].…”

Section: Introductionmentioning

confidence: 99%

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Life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus

et al. 2003

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Three new consecutive cases of life-threatening hemoptysis in adults with community-acquired pneumonia due to Panton-Valentine leukocidin-secreting Staphylococcus aureus are presented, focusing on the particular clinical presentation of this new entity. Between December 1999 and March 2001, three adults aged from 23 to 67 years were admitted to our respiratory intensive care unit for massive hemoptysis and septic shock associated with community-acquired Staphylococcus aureus pneumonia. Isolates were sent to the Centre National de Référence des Toxémies Staphylococciques in Lyon, France, where they were found to secrete Panton-Valentive leukocidin. The clinical course was similar in the three patients, with massive hemoptysis and septic shock necessitating mechanical ventilation. Two patients died rapidly; necropsy showed pulmonary vascular necrosis in one of them. The third patient recovered after appropriate antibiotic therapy. Leukocidin/neutrophil interactions in the pulmonary vasculature may cause severe hemoptysis in patients with community-acquired Staphylococcus aureus pneumonia secreting Panton-Valentine leukocidin. Adult patients with massive hemoptysis and suspected community-acquired pneumonia should receive antibiotic regimens covering Staphylococcus aureus.

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Section: Discussionsupporting

confidence: 57%