Pneumorachis associated with multiorgan infection due to Citrobacter koseri

Yamamoto, Naoki; Takegawa, Ryosuke; Seki, Masafumi; Takahashi, Kyosuke; Tahara, Kenichi; Hirose, Tomoya; Hamaguchi, Shigeto; Irisawa, Taro; Matsumoto, Naoya; Shimazu, Takeshi; Tomono, Kazunori

doi:10.1016/j.diagmicrobio.2013.08.017

Cited by 5 publications

(4 citation statements)

References 17 publications

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“…Our case manifested decreased amount of TS-lymphocyte, B-lymphocyte, and NK cells, suggesting that host immunosuppression due to anti-asthmatic drugs may be a predisposing factor in the C. koseri infection. With the exception of the patient’s comorbidities, the infection foci and pathogenic bacteria of our case were similar to those reported by Yamamoto et al and Lin et al [ 13 , 14 ]. To some extent, normal colonoscopy results had excluded the possibility of abdominal infection secondary to intestinal perforation.…”

Section: Discussionsupporting

confidence: 89%

Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature

Xian,

Ji,

Zhong

et al. 2023

Gut Pathog

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Citrobacter koseri (C. koseri) is a Gram-negative, motile, non-spore-forming facultative anaerobic bacillus belonging to the Enterobacteriaceae family. C. koseri typically utilizes citrate as the sole carbon source and constitutes part of the normal gastrointestinal flora in humans and animals. As an opportunistic pathogen, C. koseri infections are mainly observed in neonates, elderly individuals, and immunocompromised hosts. C. koseri has been one of the main etiological agents of neonatal meningitis and cerebral abscess. In recent years, an increasing number of cases have been reported in adults with severe infections caused by C. koseri. Here, we report for the first time a clinical case of concurrent C. koseri intra-abdominal infection in a patient with severe asthma and provide a brief review of the relevant literature. With this report, we hope to increase awareness and alertness among clinicians to the possibility of concurrent infection of gut commensal bacteria in asthmatic patients requiring long-term oral corticosteroid administration.

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Section: Discussionsupporting

confidence: 89%

Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature

Xian,

Ji,

Zhong

et al. 2023

Gut Pathog

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“…Navriya et al report that their patient with emphysematous pyelonephritis was managed with double J stenting. 13 The patient in Gomez et al’s case report required vasopressor and broad-spectrum antibiotics for emphysematous pyelonephritis, as did the patient reported by Yamamoto et al 14 , 15 Schomig et al had to do a lumbar puncture followed by repair of enterodural fistula for the treatment of pneumorachis caused by enterodural fistula. 16 Mahajan et al’s patient required bronchoscopic removal of mucous plugging, while another patient of Saleem et al required bronchoscopy to diagnose pneumocystis pneumonia.…”

Section: Resultsmentioning

confidence: 98%

“…36 Intra-abdominal infections (especially emphysematous pyelonephritis) with anaerobic/facultative anaerobic bacteria such as Citrobacter koseri can also generate pneumoperitoneum with subsequent invasion of air into the spinal canal. 15 Spontaneous pneumorachis can occur as a result of respiratory conditions and complications that incite barotrauma. 37 , 38 Asthma is a common, chronic respiratory disease affecting 8% of adults in the U.S.A, and some of the rare but potentially life-threatening complications of an asthma exacerbation include pneumothorax and pneumomediastinum pneumopericardium, pneumorachis, tracheoesophageal fistula, and anoxic brain injury.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Pneumorachis – A Case-Based Review

Venkataramanan¹,

George²,

Sahu³

2021

JAA

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Pneumorachis is characterized by the presence of free air in the spinal canal. It is referred by different names in literature such as epidural emphysema, intraspinal air, intraspinal pneumoc(o)ele, spinal epidural and subarachnoid pneumatosis, spinal and epidural emphysema, aerorachia, pneumosaccus, air myelogram, etc. Pneumorachis can be broadly classified as traumatic, iatrogenic, or spontaneous. In this case-based review, we present a case of spontaneous pneumorachis secondary to asthma exacerbation. This is followed by a systematic review of all cases of spontaneous pneumorachis identified in PubMed. The aim of this review is to understand the pathophysiology, common causes and the management of spontaneous pneumorachis.

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“…Gram-negative rods, including E. coli and K. pneumoniae , produce endotoxins and frequently induce extreme inflammation and sepsis. 3 , 7 , 11 …”

Section: Discussionmentioning

confidence: 99%

Ability of procalcitonin to diagnose bacterial infection and bacteria types compared with blood culture findings

Watanabe¹,

Oikawa²,

Hariu³

et al. 2016

IJGM

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Procalcitonin (PCT) and C-reactive protein serve as biomarkers of infection in patients with sepsis/bacteremia. The present study assessed the clinical characteristics of 280 patients with suspected sepsis who were admitted to Tohoku Medical and Pharmaceutical University Hospital between January 2012 and December 2013. Among the patients, 133 and 147 were positive and negative for PCT, respectively. Patients who were PCT positive were older and more frequently male, had reduced levels of platelets and albumin, and increased levels of aspartate aminotransferase, alanine aminotransferase, blood urea nitrogen, creatinine, and C-reactive protein. Patients who were PCT positive had significantly higher blood culture positivity compared with those who were PCT negative, and the sensitivity and specificity of PCT for detecting positive blood cultures were 74.5% and 59.1%, respectively. Escherichia coli was detected in PCT-positive patients, whereas Staphylococcus epidermidis and Staphylococcus lugdunensis were frequently detected in PCT-negative patients. Levels of PCT were higher in the patients infected with gram-negative rods than those with gram-positive cocci. Furthermore, extended-spectrum β-lactamase (ESBL)-producing bacteria cases showed higher levels of PCT than those of non-ESBL cases. These results suggest that PCT may be a useful biomarker of sepsis, and it might serve as a strong tool to detect patients with severe gram-negative rod bacteremia including ESBL-producing bacteria cases early due to its relative high sensitivity.

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Pneumorachis associated with multiorgan infection due to Citrobacter koseri

Cited by 5 publications

References 17 publications

Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature

Severe asthma patient with secondary Citrobacter koseri abdominal infection: first case report and review of the literature

Spontaneous Pneumorachis – A Case-Based Review

Ability of procalcitonin to diagnose bacterial infection and bacteria types compared with blood culture findings

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