This chapter addresses biomedical sensors, which are important factors for the quality of measurement of biological and physiological variables, and thus deserve close attention both with respect to the medical functions and the technical requirements. There are special demands for biomedical sensors, particularly for invasive sensors that must pass sterilization by temperature or radiation at much higher levels than the rest of the medical equipment. On the other hand, miniaturization, mechanical strength, electrical safety, and sterility are important elements of the sensor design process. The sensor determines the accessibility, spatial resolution, accuracy, sensitivity, selectivity, and response time of the measurement. In order to convert the parameter of interest into an electrical signal suited for medical use, a transducing element is necessary. Knowledge of the complete chain of transducer materials, their electrical properties, and integration with bio-amplifiers are therefore necessary to design high-quality biomedical sensors.