PNPLA3 as a driver of steatotic liver disease: navigating from pathobiology to the clinics via epidemiology
Ralf Weiskirchen,
Amedeo Lonardo
Abstract:Steatotic liver disease (SLD), particularly metabolic dysfunction-associated SLD, represents a significant public health concern worldwide. Among the various factors implicated in the development and progression of this condition, the patatin-like phospholipase domain-containing protein 3 (PNPLA3 ) gene has emerged as a critical player. Variants of PNPLA3 are associated with altered lipid metabolism, leading to increased hepatic fat accumulation and subsequent inflammation and fibrosis. Understanding the role… Show more
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