PO-0134 Cow’s Milk Protein Allergy: Oral Food Challenge Before 12 Months Of Age?

Abstract

There were 121 positive cultures positive, 79.3% in patients obeying the defined criteria and 91.7% with clinical predictors of positivity. Campylobacter was the most frequently identified agent (68.6%), followed by Salmonella. Campylobacter decreased within an increasing age whilst Salmonella showed an inverse pattern. Campylobacter was the most frequently identified agent throughout all seasons of the year, followed by Salmonella, except in the winter when Yersinia took the second place. Discussion Sticking to accepted criteria for stool collection and/ or to defined clinical features, increasing the yield of stool cultures. PO-0132 ACID REFLUX INTO THE OESOPHAGUS AND EXERCISE:A PROSPECTIVE STUDY IN CHILDREN C Pacchiarotti, M Barreto, M Campisano, F La Penna, A Bozzone, C Casini, I Caiazzo, A Crescenzi, MP Villa. NESMOS Department, Pediatric Unit Sant'Andrea Hospital, Roma, Italy 10.1136/archdischild-2014 Background and aims It has been reported that gastro-oesophageal reflux (GOR) can be induced by exercise, as described in adult subjects; studies in children are lacking. We sought whether the presence of acid in the oesophagus may increase with exercise and its potential relationship with atopy and lung function in children. Methods We recruited 45 patients (M/F: 30/15) aged 11 ± 2.7 years with reported exercise-induced respiratory symptoms; subjects were asked for frequency of gastrointestinal symptoms. All patients did lung function before and after 24-h gastro-oesophageal (GO) pH monitoring; they also underwent exercise testing (treadmill) before removing GO catheter. GO-pH was also analysed for 6 min intervals before, during and after exercise. The gastro-oesophageal reflux disease (GORD) was defined as a 24-hour reflux index (IR) ≥ 4.5% and/ or symptom index ≥ 50%. Total serum IgE levels were also assessed. Results GORD was found in 11/45 (24.4%) of our patients; these children had also a higher IR score during exercise than patients without GORD (7.1 ± 18.5 vs 0.5 ± 2.3, p < 0.05). A fall of GO-pH was recorded during exercise, greater in children with GORD as compared with those without (17.2 ± 42.2 vs 0.9 ± 6.4, p = 0.03). The exercise-induced fall in GO-pH was associated with frequent gastrointestinal symptoms and correlated with IgE levels and baseline FEV 1 % (IgE: r = -0.37, FEV1%: r = -0.31, p < 0.05 for both). Conclusions Our results suggest that oesophageal acidity increase with exercise, particularly in atopic children with frequent gastrointestinal symptoms and low baseline respiratory function. Background and aims Several study have been reported that modifying vagus nerve control of transient lower esophageal sphincter relaxation can induce improvement of gastroesophageal reflux disease (GERD). Our aim was to evaluate the efficacy of osteophatic treatment (OMT) in infants with GERD. Methods We enrolled 40 infants (M/F:24/16), age ranged 1-18 months (median 4 month) attending for persistent reflux. Each patient performed I-GERQ-R questionnaire and ultrasonography of the gastro-esophageal j...