PO-0251 Tuberculosis In Children: A Study Of 32 Cases

Abstract

Medical treatment is rarely recommended. The aim of our study is to evaluate follow-up and response to medical treatment in patients affected by hydatid cystis (HC). Methods We conducted a retrospective study about all cases of HC treated by albendazole in paediatrics department of Hedi Chaker University Hospital in Sfax over a period of 10 years (2004-2013). Results We report 6 cases of HC treated medically. Ages ranged between 2 and 8 years. Diagnosis was based on laboratory and imaging studies. Hydatid cystis had multiple localizations in all of cases: multiple hepatic HC (1 case), bilateral pulmonary HC (1 case), hepatic and pulmonary HC (1 case), hepatic and splenic HC, hepatic, splenic and renal HC and hepatic, pulmonary, cardiac and pancreatic HC. All patients were treated with Albendazole (10 mg/kg/day during 6 to 24 months). Surgical treatment was associated in 4 cases. The outcome was favourable in all cases. Conclusions Surgery remains the ideal treatment for hydatid cysts. However, medical treatment with albendazole can be efficient and can, in some circumstances, replace surgery especially in case of multiple locations.

Clinical Manifestation of Cytomegalovirus-Associated Protein-Losing Enteropathy in Children

“…However, CMV-associated PLE is poorly considered. In our study, the most commonly presenting symptoms of CMV-associated PLE were vomiting followed by generalised oedema associated with unspecific symptoms suggesting a viral illness, similar to the few case reports and short case series depicting this disease in children [12][13][14][23][24][25][26][27]. To characterise all the manifestations of CMV-associated PLE, we considered the immunological status of patients and did not just focus on gastropathy, as is often the case [12][13][14][23][24][25][26].…”

“…Thus, early detection is important to avoid severe CMV disease in immunosuppressed patients [ 31 ], and CMV infections are commonly sought in this population. On the other hand, CMV-associated PLE is described as being benign and self-limited in immunocompetent children [ 12 , 13 , 14 , 24 , 26 ]. However, in our study, some immunocompetent children had an altered state, needed emergency care and five of them (23.8%) had a severe course.…”

“…The median time between onset of symptoms and hypoalbuminemia was 9.5 days [6. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] in the immunocompetent group and 14 days [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] in the immunosuppressed one (p = 0.88) (Table 2). For both immunocompetent and immunosuppressed populations, the most frequent symptoms were vomiting, prevailing in immunocompetent patients (85.7% versus 50%, CI [1.2; 39.2], p = 0.02), acute diarrhoea (66.7% and 86.4%, CI [0.05; 1.7], p = 0.16), anorexia (66.7% and 68.2%, CI [0.2; 4], p = 1), asthenia (52.4% and 50%, CI [0.3; 4.3], p = 1) and fever (47.6% and 54.5%, CI [0.2; 2.9], p = 0.76).…”

“…However, faced with generalised oedema in paediatric emergency departments, the physician will consider cardiac, renal or hepatic causes, which require specific and urgent treatments, and will perform the first inevitable biological tests in accordance, without considering a CMV infection [ 11 ]. In CMV-associated PLE, the biological tests will reveal hypoproteinaemia and hypoalbuminemia, such as for some renal causes, but without urinary test abnormalities [ 12 , 13 , 14 ]. However, as CMV-associated PLE is not a common diagnosis, unnecessary tests will then be performed to try to understand the cause of oedema.…”

“…Nutrients 2023, 15, 2844 2 of 11 considering a CMV infection [11]. In CMV-associated PLE, the biological tests will reveal hypoproteinaemia and hypoalbuminemia, such as for some renal causes, but without urinary test abnormalities [12][13][14]. However, as CMV-associated PLE is not a common diagnosis, unnecessary tests will then be performed to try to understand the cause of oedema.…”