PO-0812 Neurodevelopmental Outcomes Of Premature Infants With Severe Intraventriculer Hemorrhagea

Abstract

Objective Our objective was to determine the neurodevelopmental outcome at 18–24 months’ of corrected age (CA) in preterm infants with severe intraventricular haemorrhage (IVH). Methods This was a retrospective cohort study of all preterm infants who were <37 weeks’ gestation, had Grade 3–4 IVH. A comprehensive assessment including hearing, vision, neurological and developmental evaluation with Bayley Scales of Infant Development, Second edition (BSID II) was performed by the experienced researchers at 18 to 24 months’ CA. Results A total of 138 were diagnosed as severe IVH (Grade 3–4). Median Apgar score (p < 0.01) and resuscitation at birth (p < 0.01) were significantly different for group 1, group 2 and group 3. The use of catheterization, need for mechanical ventilation, need for phototherapy, retinopathy of premature and bronchopulmonary dysplasia were significantly higher in-group 1 compared to group 2 and 3 (p < 0.001, p < 0.001, p < 0.01, p < 0.01 and p = 0.014 respectively). The duration of hospitalisation and mortality rates consistent with the degree of prematurity and were significantly higher in-group 1 compared to group 2 and 3 (p = 0.03 and p = 0.01). Among the long-term outcomes; the rates of CP and NDI did not differ between the groups (p = 0.68 and p = 0.068). Conclusion Our results demonstrated that long-term outcomes of preterm infants did not differ between the groups classified according to the birth weight at 2 years of age. This has leaded to the conclusion that severe IVH is alone represents a significant risk factor for poor neurodevelopmental outcome in this already high-risk population.