PO-1073 Circadian variation in radiation induced mucositis in head and neck malignancies - retrospective analysis

Kuriakose, V.G.; Jayakumar, K.L.; Anandh, S.; Anand, R.; Susan, Shur-Fen Gau

doi:10.1016/s0167-8140(15)41065-5

Cited by 2 publications

(3 citation statements)

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“…Our findings showed that restricting chemotherapy and/or radiotherapy to specific time of the day might generally reduce treatment adverse events and relatively increases therapeutic response and survival rates in head and neck cancer patients (Bjarnason et al 2009;Brolese et al 2021;Elicin et al 2021;Elzahi et al 2020;Goyal et al 2009;Gu et al 2020;Kuriakose et al 2016;Lin et al 2013;Tsuchiya et al 2018;Verma et al 2014;Yang et al 2013;Zhang et al 2013Zhang et al , 2018Zhang et al , 2021. However, these studies' findings and clinical implications should be interpreted with caution due to methodological limitations.…”

Section: Discussionmentioning

confidence: 64%

“…Two retrospective studies included in this review investigated whether radiotherapy timing could influence oral mucositis severity in managing head and neck cancer. Indeed, both studies demonstrated that radiation-induced oral mucositis was significantly lower when patients were exposed to radiotherapy in the morning (Gu et al 2020;Kuriakose et al 2016). In contrast, Brolese et al (2021) reported that seasonality, not daytime (morning/evening), was a predictor for radiation-induced oral mucositis severity.…”

Section: Human Studiesmentioning

confidence: 99%

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Chronotherapy in dentistry: A scoping review

Abusamak

Al-Tamimi

Al-Waeli

et al. 2023

Chronobiology International

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The circadian clock modulates almost all vital aspects of our physiology and metabolism, including processes relevant to dentistry, such as healing, inflammation and nociception. Chronotherapy is an emerging field aiming to improve therapeutic efficacy and decrease adverse effects on health outcomes. This scoping review aimed to systematically map the evidence underpinning chronotherapy in dentistry and to identify gaps in knowledge. We conducted a systematic scoping search using four databases (Medline, Scopus, CINAHL and Embase). We identified 3908 target articles screened by two blinded reviewers, and only original animal and human studies investigating the chronotherapeutic use of drugs or interventions in dentistry were included. Of the 24 studies included, 19 were human studies and five were animal studies. Chrono-radiotherapy and chrono-chemotherapy reduced treatment side effects and improved therapeutic response, leading to higher survival rates in cancer patients. Animal studies reported that tooth movement and periodontal tissue response to orthodontic forces follow a diurnal rhythm that might influence bone metabolism. Profound and prolonged local anesthesia could be achieved when injected in the evening. Although the overall quality of the included studies was low, chronotherapy applications in dentistry seem to have favourable outcomes, especially in head and neck cancer treatments.

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Section: Discussionmentioning

confidence: 64%

Section: Human Studiesmentioning

confidence: 99%

Chronotherapy in dentistry: A scoping review

Abusamak

Al-Tamimi

Al-Waeli

et al. 2023

Chronobiology International

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“…The similar results was seen in the study conducted by Kuriakose et al, the median time to develop grade 3 or 4 oral mucositis was found to be 6 weeks in the morning arm and 5 weeks in the evening arm. 26 The impact of smoking on oral mucositis has been studied extensively. In our study, it was found that patients who were smokers or had previous history of smoking had significant grade 3 oral mucositis and the p value was found to be significant (p=0.005).…”

Section: Treatment Toxicitymentioning

confidence: 99%

A Comparative Study Assessing the Different Patterns of Radiation Reactions in Head and Neckcancer Patients Undergoing Radiation Therapy at Different Times of the Day-in the Morning Versus Evening

Ponna¹,

Devi²,

Baidya³

et al. 2021

IJAR

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Background: Human oral mucosa, is a prime target for radiation induced toxicity in patients undergoing radiotherapy for head and neck cancer. The oral cavity is highly susceptible to direct and indirect toxic effects of cancer chemotherapy and ionizing radiation. In our study we investigated the role of chronotherapy with respect to radiation induced mucositis occurring in the normal oral mucosa and treatment response in tumor tissue in cancer patients undergoing radiation therapy to head and neck region. Materials and Methods: This non-randomized clinical study was done to compare the two different timing schedules in the management of head and neck cancer by external beam radiation therapy by cobalt-60 (Theratron780C). In morning arm (arm A), Patients received external beam radiotherapy (EBRT) by cobalt-60 with SSD of 80cm with daily fractions, five days a week, between 8AMÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â–10 AM whereas in evening arm (arm B), patients received EBRT by cobalt-60 with daily fractions, five days a week, between 3PMÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â–5 PM. Both the arms received same radiation regimen. Results: The study concluded that in the morning arm the onset of oral mucositis was observed to be significantly delayed and the duration of mucositis was also significantly shorter as compared to the evening arm. Statistically significant difference in severity of mucositis was found between the two arms. Conclusion: Since there is no active measure to minimize normal tissue toxicity, chronomodulated radiotherapy would be a feasible and cost effective treatment strategy that can be put into clinical practice.

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PO-1073 Circadian variation in radiation induced mucositis in head and neck malignancies - retrospective analysis

Cited by 2 publications

References 0 publications

Chronotherapy in dentistry: A scoping review

Chronotherapy in dentistry: A scoping review

A Comparative Study Assessing the Different Patterns of Radiation Reactions in Head and Neckcancer Patients Undergoing Radiation Therapy at Different Times of the Day-in the Morning Versus Evening

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