PO-13 Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study (STAC)

Crobach, Monique J. T.; Anijs, R.J.S.; Brækkan, Sigrid Kufaas; Severinsen, Marianne Tang; Hammerstrøm, Jens; Skille, Hanne; Kristensen, Søren Risom; Paulsen, Benedikte; Tjønneland, Anne; Versteeg, Henri H.; Overvad, Kim; Hansen, John‐Bjarne; Næss, Inger Anne; Cannegieter, S.C.

doi:10.1016/s0049-3848(21)00186-9

Cited by 2 publications

(3 citation statements)

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“…VTE is a significant independent predictor of early mortality in patients with cancer of all stages and types. 1,3,[8][9][10]22 The in-hospital mortality rate in our study was 18%, which is higher than that in other studies (11.36%-16.3%). 10,23,24 However, unlike our study in which all patients had advanced-stage disease and most had a compromised functional status, these previous studies mainly included patients with local or regional disease.…”

Section: Discussioncontrasting

confidence: 75%

“…[4][5][6] The presence of VTE in this population has been associated with a worse prognosis, with an approximately 4-times higher risk of death after an acute thrombotic event. [7][8][9] Studies have shown that VTE not only impacts the 1-year survival rate but also impacts in-hospital mortality within 7, 14, and 30 days. 8,10 Additionally, patients with cancer and VTE have higher rates of hospital admission, bleeding, and recurrence than cancer-free patients with VTE.…”

Section: Introductionmentioning

confidence: 99%

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Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism

Reyes,

Ruiz-Talero,

Arenas

et al. 2023

J Int Med Res

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Objective To identify factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer who present with venous thromboembolic disease (VTE). Methods In this prospective cohort, in-hospital and outpatient survival rates up to 180 days were analyzed using Kaplan–Meier curves. Cox regression was used to identify factors associated with different survival functions. Results One hundred patients were analyzed (median age, 67.5 years; 75% with Charlson index of <10; 69% with Eastern Cooperative Oncology Group (ECOG) score of 3–4). In-hospital mortality was 18%, and the median time from admission to death was 11 days (interquartile range, 1–61 days). Factors significantly associated with in-hospital mortality were the ECOG score and thrombocytopenia. The 180-day mortality rate was 52%, with deaths mainly occurring in the first 90 days since VTE diagnosis. Additional factors significantly associated with outpatient mortality included male sex and neoplasms with a high risk of thrombosis (lung, pancreas, stomach, uterus, bladder, and kidney neoplasms). Conclusion Patients with stage IV cancer and acute VTE have short survival. Poor prognostic factors are thrombocytopenia, the ECOG score, and certain types of cancer. These results may help physicians individualize decisions regarding initiation and continuation of anticoagulant therapy.

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Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism

Reyes,

Ruiz-Talero,

Arenas

et al. 2023

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…3). 10 In severe cases, this can lead to the formation of peripheral venous thrombosis, 11 affecting clinical outcomes and prognoses in patients with cancer.…”

Section: Factors Affecting the 3-year Survival Rate After Esophageal ...mentioning

confidence: 99%

Clinical value of measuring plasma D-dimer levels in patients with esophageal cancer

Chen,

Xu,

Zhang

et al. 2024

Preprint

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Background Esophageal cancer represents a significant public health concern; however, reliable diagnostic and prognostic markers have not been established. This study aimed to investigate the clinical value of plasma D-dimer levels in patients with esophageal cancer. Methods Overall, 120 patients with esophageal cancer who underwent radical surgical resection at our department between January 2019 and 2020 were included (esophageal cancer group). Plasma D-dimer levels were measured preoperatively and on postoperative days 1 and 14. Additionally, 60 healthy participants (control group) with measured plasma D-dimer levels were included. The preoperative D-dimer levels and positive D-dimer test rates were compared between the groups. The 3-year survival rate in patients with esophageal cancer was calculated using the Kaplan–Meier method. Results Preoperative D-dimer concentrations were significantly higher in the esophageal cancer group than in the control group. The positivity rate in the esophageal cancer group (35.0%, 42/120) was significantly higher than that in the control group (15%, 9/60). D-dimer concentrations were significantly higher 1 day postoperatively than preoperatively. Conversely, D-dimer concentrations were significantly lower 14 days postoperatively than preoperatively. Patients in the esophageal cancer group with plasma D-dimer concentrations ≤ 0.5 µg/mL had significantly higher 3-year survival rates than those with higher concentrations. In the logistic multivariate analysis, tumor pathological stage and preoperative plasma D-dimer levels were independent prognostic factors of 3-year survival rates in patients with esophageal cancer. Conclusion Plasma D-dimer concentrations are clinically valuable in esophageal cancer diagnosis, postoperative recurrence monitoring, and prognosis prediction.

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PO-13 Survival after cancer-related venous thrombosis: the Scandinavian Thrombosis and Cancer Study (STAC)

Cited by 2 publications

References 0 publications

Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism

Factors associated with in-hospital and outpatient survival of patients with different types of stage IV cancer and venous thromboembolism

Clinical value of measuring plasma D-dimer levels in patients with esophageal cancer

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