PO-84 Expression of Tissue Factor (TF) and growth factor receptors on pancreatic cell lines: correlation with TF activity and cell invasion

Echrish, Hussein; Madden, Leigh A.; Greenman, John; Maraveyas, Anthony

doi:10.1016/s0049-3848(10)70134-1

Cited by 2 publications

(3 citation statements)

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“…Cancer patients have a significantly higher number of circulating EV compared to healthy controls ( 243 – 245 ). For example, pancreatic cancer patients undergoing chemotherapy are known to possess elevated levels of TF-bearing EV, thus increasing the risk of VTE ( 246 ). This phenomenon was observed by Zwicker et al when they concluded that TF-bearing EVs were associated with VTE in cancer patients ( 244 ).…”

Section: Tumor-derived Apov and Coagulationmentioning

confidence: 99%

Tumor-Derived Apoptotic Vesicles: With Death They Do Part

Muhsin-Sharafaldine

McLellan

2018

Front. Immunol.

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Tumor cells release lipid particles known as extracellular vesicles (EV) that contribute to cancer metastasis, to the immune response, and to thrombosis. When tumors are exposed to radiation or chemotherapy, apoptotic vesicles (ApoVs) are released in abundance as the plasma membrane delaminates from the cytoskeleton. Recent studies have suggested that ApoVs are distinct from the EVs released from living cells, such as exosomes or microvesicles. Depending on their treatment conditions, tumor-released ApoV have been suggested to either enhance or suppress anti-cancer immunity. In addition, tumor-derived ApoV possess procoagulant activity that could increase the thrombotic state in cancer patients undergoing chemotherapy or radiotherapy. Since ApoVs are one of the least appreciated type of EVs, we focus in this review on the distinctive characterization of tumor ApoVs and their proposed mechanistic effects on cancer immunity, coagulation, and metastasis.

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Section: Tumor-derived Apov and Coagulationmentioning

confidence: 99%

Tumor-Derived Apoptotic Vesicles: With Death They Do Part

Muhsin-Sharafaldine

McLellan

2018

Front. Immunol.

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“…Aside from its traditional haemostatic role, surface TF is thought to further potentiate cancer progression, through an enhancement of angiogenesis and by facilitating metastasis, and possesses roles in primary tumour growth [21,22]. In vitro, high levels of surface TF expression have been further correlated with cell invasion in pancreatic cancer cell lines [23].…”

Section: The Association Of Vte With Tf Expression Levels On Tumour Cmentioning

confidence: 99%

“…Interestingly, recent studies have concluded that TF cell surface expression was explicitly linked to the procoagulant activity (PCA) of pancreatic, breast, colorectal and head and neck squamous cell carcinoma (HNSCC) tumour cell lines [23,24]. Immunohistochemical staining revealed the highest and most consistent intensity of TF expression in tumours typically associated with high VTE incidence such as lung, HNSCC and pancreatic cancers, with lower and less consistent staining in breast, renal and prostate cancers [25].…”

Section: The Association Of Vte With Tf Expression Levels On Tumour Cmentioning

confidence: 99%