Po16-458 Serum Dehydroepiandrosterone Sulfate Levels Predict Longevity in Men (27-Year Follow-Up Study)

Enomoto, Makoto; Adachi, Haruo; Furuki, Kumiko; Kumagae, Shun-ichi; Otsuka, Maki; Shigetoh, Yoshiyuki; Fukami, Ako; Satoh, Atsushi; Imaizumi, T.

doi:10.1016/s1567-5688(07)71468-x

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“…Although previous studies have not chiefly examined DHEAS change, the data from the current study agree with previous observations 2–8 . The current study confirmed that serum DHEAS is lower in women than in men and decreases with age.…”

Section: Discussionsupporting

confidence: 91%

“…Although most participants in this very old cohort declined minimally, DHEAS decline was nonetheless noted in a substantial number of individuals. DHEAS was negatively correlated with age into the ninth decade of life, similar to reports in younger individuals 2–8 . Cross‐sectionally, lower DHEAS was associated with certain health characteristics.…”

Section: Discussionsupporting

confidence: 75%

“…Several factors strengthen these results. First, a large sample of adults was analyzed that, on average, was older than those in previous studies 4–9 . Second, there were substantial numbers of women and men, enabling sex‐specific associations to be identified, including an important age–sex interaction.…”

Section: Discussionmentioning

confidence: 99%

“…Earlier studies reported no association with mortality in women, whereas later studies indicated that higher DHEAS is associated with lower all‐cause mortality and cardiovascular‐specific mortality in men 4 . More‐recent reports indicate that low DHEAS is associated with greater mortality in men and women 5–7 . One study found that low and high DHEAS each confer greater mortality in disabled older women (U‐shaped association) and that the slope and variability of DHEAS change, rather than baseline DHEAS level, is associated with greater mortality 8,9 .…”

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confidence: 99%

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Cardiovascular Disease Is Associated with Greater Incident Dehydroepiandrosterone Sulfate Decline in the Oldest Old: The Cardiovascular Health Study All Stars Study

Sanders

Boudreau

Cappola

et al. 2010

J American Geriatrics Society

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OBJECTIVES-To describe cross-sectional and longitudinal associations with dehydroepiandrosterone sulfate (DHEAS) and change in DHEAS with age. DESIGN-Longitudinal cohort study.SETTING-Pittsburgh, Pennsylvania. PARTICIPANTS-CardiovascularHealth Study All Stars study participants assessed in 2005/06 (N =989, mean age 85.2, 63.5% women, 16.5% African American).Address correspondence to Jason Sanders, 4614 Fifth Ave, Apt 217, Pittsburgh, PA 15213. sanders.jason@medstudent.pitt.edu. The work from which this manuscript was derived appeared as an abstract at the 2009 American Geriatrics Society Annual Meeting, Chicago, Illinois, April 29-May 2, where it won the Presidential Poster Award in the epidemiology category. Conflict of Interest:The editor in chief has reviewed the conflict of interest checklist provided by the authors and has determined that the authors have no financial or any other kind of personal conflicts with this paper. Financial Disclosure: The research reported in this article was supported by National Institute on Aging (NIA) Grant AG-023629. CHS was supported by Contracts N01-HC-85079 through N01-HC-85086, N01-HC-35129, N01 HC-15103, N01 HC-55222, N01-HC-75150, and N01-HC-45133 and Grant U01 HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by NIA Grants R01 AG-15928, R01 AG-20098, and AG-027058 , DHEAS was lower in women and subjects with cardiovascular disease (CVD) and chronic pulmonary disease and higher for African Americans and subjects with hypertension and high cholesterol. Mean DHEAS change was greater in men (− 0.200 μg/mL) than in women (− 0.078 μg/mL) (P<.001). Each 1-year increase in age attenuated the effect of male sex by 0.01 μg/mL (P =.009), abolishing the sex difference in DHEAS change by age 79. Presence of CVD before the study period was associated with greater absolute DHEAS change (β = − 0.04 μg/ mL, P =.04) and with the fourth quartile of DHEAS change versus the first to third quartiles (odds ratio =1.46, 95% confidence interval =1.03-2.05). Previous studies have investigated the outcomes that DHEAS predicts and sought to define its association with mortality independent of age. Data supportive of this are conflicting. 4 Earlier studies reported no association with mortality in women, whereas later studies indicated that higher DHEAS is associated with lower all-cause mortality and cardiovascular-specific mortality in men. 4 More-recent reports indicate that low DHEAS is associated with greater mortality in men and women. [5][6][7] One study found that low and high DHEAS each confer greater mortality in disabled older women (U-shaped association) and that the slope and variability of DHEAS change, rather than baseline DHEAS level, is associated with greater mortality. 8,9 These reports suggest that a disordered neuro-endocrine axis or altered homeostasis increases mortality rather than a unidirectional shift in hormone levels...

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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