Po222 Age-Related Skeletal Muscle Loss as an Independent Predictor of Nafld Risk in Korean Women With Type 2 Diabetes

Choi, Young-Wook; Kim, S.-k.; Kwak, Jin-Young; Park, S.W.; Lee, E.-J.; Huh, Kap-Bum

doi:10.1016/s0168-8227(14)70516-9

Cited by 3 publications

(4 citation statements)

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“…[ 16 ] Finally, five cross-sectional studies with 27,804 participants were included in the meta-analysis. [ 12 13 15 16 18 ] The literature retrieval, review, and selection process are shown in Figure 1 . The characteristics and quality assessment of the studies are presented in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

“…Only three studies used dual energy X-ray absorptiometry which is considered as the gold standard for muscle mass measurement. [ 12 13 16 ] Other studies used bioelectrical impedance analysis to estimate the skeletal muscle mass which may have a lower accuracy. [ 15 18 ] Second, all the included studies were cross-sectional in nature.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, previous epidemiologic studies have suggested an association between sarcopenia and the development of NAFLD even though the results were inconsistent. [ 12 13 14 15 16 17 18 ] This systematic review and meta-analysis was conducted to summarize all available evidence with the aim to better characterize this relationship.…”

Section: Introductionmentioning

confidence: 99%

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Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis

Wijarnpreecha¹,

Panjawatanan²,

Thongprayoon³

et al. 2018

Saudi J Gastroenterol

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Background/Aim:The association between sarcopenia and nonalcoholic fatty liver disease (NAFLD) has been suggested by recent epidemiological studies, although the results have been inconsistent. This meta-analysis was conducted to summarize all available data and estimate the risk of NAFLD among patients with sarcopenia.Materials and Methods:A comprehensive literature review was conducted using MEDLINE and EMBASE databases through November 2016 to identify all studies that compared the risk of NAFLD among patients with sarcopenia versus those without sarcopenia. Effect estimates from each study were extracted and combined using the random-effect, generic inverse variance method of DerSimonian and Laird.Results:Five cross-sectional studies with 27,804 participants met the eligibility criteria and were included in the meta-analysis. The risk of NAFLD in patients with sarcopenia was significantly higher than those without sarcopenia with the pooled odds ratio of 1.54 (95% confidence interval, 1.05–2.26). The statistical heterogeneity was high with an I2of 83%.Conclusions:A significantly increased risk of NAFLD among patients with sarcopenia was observed in this study.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcopenia and risk of nonalcoholic fatty liver disease: A meta-analysis

Wijarnpreecha¹,

Panjawatanan²,

Thongprayoon³

et al. 2018

Saudi J Gastroenterol

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“…After the exclusion of 350 duplicates, 135 reviews and comments, 226 animal studies, 586 irrelevant studies, and 17 articles without concrete data ( Fig. 1), 19 articles were eventually included in our meta-analysis [5][6][7][8][9][10][12][13][14][15][16][17][18][19][20][21][22][23][24]. Characteristics of all the studies included are listed in Table 1, among which, 2 were in retrospective cohort design and 17 were in a cross-sectional design.…”

Section: Study Identification and Literature Characteristicsmentioning

confidence: 99%

Relationship between relative skeletal muscle mass and nonalcoholic fatty liver disease: a systematic review and meta-analysis

et al. 2019

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Background and Aim Nonalcoholic fatty liver disease (NAFLD) has gradually become one of the most common chronic liver diseases in the world. More and more evidence shows that low skeletal muscle mass index (SMI) may play a role in the development of NAFLD. Our aim was to quantify the association between SMI, sarcopenia and the presence and severity of NAFLD. Methods We systematically searched English relevant studies from PubMed, Embase, the Web of Science and the Cochrane Library updated to December 20th, 2018. Studies in which SMI was compared between NAFLD cases and controls were included. So were studies concerning the odds ratio (OR) of NAFLD, non-alcoholic steatohepatitis (NASH) and significant fibrosis in sarcopenia patients. Pooled weighted mean differences and ORs were calculated. Results Of the 1331 retrieved studies, 19 articles were included. SMI level in NAFLD patients was 1.77 (95% CI 1.15, 2.39) lower than that in normal controls. We also found a significantly higher occurrence risk of NAFLD (OR = 1.33, 95% CI 1.20 to 1.48), NASH (OR = 2.42, 95% CI 1.27 to 3.57) and NAFLD-related significant fibrosis (OR = 1.56, 95% CI 1.34, 1.78) in sarcopenia subjects. Conclusions SMI level in patients with NAFLD was lower than healthy people, and patients with sarcopenia have higher occurrence risk of NAFLD, as well as its advanced stages including NASH or NAFLD-related significant fibrosis. Further well-designed prospective studies are required to strengthen the arguments.

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