PO5-159 THE −11377 C&gt;G PROMOTER VARIANT OF THE ADIPONECTIN GENE, PREVALENCE OF CORONARY ATHEROSCLEROSIS, AND INCIDENCE OF VASCULAR EVENTS IN MEN

Hoefle, G.; Muendlein, Axel; Saely, C.H.; Risch, L.; Rein, Philipp; Koch, Lothar; Schmid, F; Aczél, S.; Marte, Thomas; Langer, P; Drexel, Heinz

doi:10.1016/s1567-5688(07)71169-8

Cited by 4 publications

(8 citation statements)

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“…Age, sex, body mass index (BMI), systolic blood pressure, mean arterial pressure, triglycerides (ln-transformed), high-density lipoprotein (HDL) cholesterol, 2-h post-oral glucose tolerance test (OGTT) glucose (ln-transformed), homeostasis model assessment of insulin resistance index (HOMA-IR) (ln-transformed), and high-sensitivity C-reactive protein (ln-transformed) were allowed to enter into the stepwise model. associated with diabetes, severe forms of obesity, carotid intima media thinkness, and other cardiovascular risks (33)(34)(35)(36)(37). This SNP was associated with adiponectin level in Caucasians (10,33,38) and also with diabetic nephropathy in female type 1 diabetic patients, with the presence of the minor G allele shown to destroy the binding site of transcriptional stimulatory protein, Sp1 (39).…”

Section: Discussionmentioning

confidence: 97%

Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

Ong¹,

Li²,

Tso

et al. 2010

European Journal of Endocrinology

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Objective: Low plasma adiponectin level can predict the development of hypertension after 5 years in our population. We therefore investigated whether single-nucleotide polymorphisms (SNPs) in the adiponectin gene influenced plasma adiponectin level and whether they were associated with hypertension. Design and methods: We genotyped 14 tagging SNPs in 1616 subjects with persistent normotensive or hypertensive status during a 6.4-year follow-up period in the Hong Kong Cardiovascular Risk Factor Prevalence Study-2 (CRISPS-2). Plasma adiponectin level was measured in 1385 subjects using in-house sandwich ELISA. Results: The minor G allele of the SNP rs266729 was significantly associated with higher odds of hypertension (odds ratio (95% confidence interval)Z1.49 (1.13-1.95), PZ0.0044) after adjusting for covariates. In stepwise multiple logistic regression, this SNP (PZ0.006) was a significant independent factor of hypertension, together with age (P!0.001), body mass index (P!0.001), triglycerides (PZ0.021), and insulin resistance index (P!0.001). Among the 14 SNPs, rs266729 (bZK0.067, PZ0.0037), K10677COT (bZ0.069, PZ0.0027), rs182052 (bZK0.097, P!0.0001), and rs12495941 (bZ0.103, P!0.0001) were significantly associated with adiponectin level after adjusting for covariates. No significant sex interaction was found for the associations of SNPs with hypertension and adiponectin level. Similar results were obtained in haplotype analysis. Conclusion: In our population, genetic variants in the adiponectin gene influenced plasma adiponectin levels, and one of them was associated with hypertension. This study has provided further evidence for a role of adiponectin in the development of hypertension.

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Section: Discussionmentioning

confidence: 97%

Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

Ong¹,

Li²,

Tso

et al. 2010

European Journal of Endocrinology

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“…Epidemiologic studies assess that single-nucleotide polymorphisms (SNPs) and some haplotypes present in the ACDC gene, promoter region included, are associated with obesity [3,[17][18][19] , as well as with T2DM, metabolic syndrome (MS) and coronary artery disease in some populations [3,[20][21][22] .…”

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confidence: 99%

Molecular Analysis of the Adiponectin Gene in Severely Obese Patients from Southern Italy

et al. 2008

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Background: Severe obesity is a major worldwide public health concern affecting 0.5–5% of the adult population. Adiponectin (Acpr30), an adipokine secreted from adipocytes, shows pleiotropic beneficial effects on obesity and related disorders. In this study, sequence analysis of Acpr30 gene (ACDC) was performed in a highly selected population of severely obese young adult patients from Southern Italy to investigate the associations between polymorphisms in the ACDC gene and the development of severe obesity concomitantly with other features of the metabolic syndrome. Methods: The ACDC gene was analyzed by direct sequencing in the severely obese patients (n = 220) and compared to healthy controls (n = 116). The associations between the ACDC gene single-nucleotide polymorphisms (SNPs) and the levels of serum Acpr30 as well as the correlation with the presence of severe obesity jointly associated with other features of the metabolic syndrome were also investigated. Total serum Acpr30 concentrations were measured by the ELISA method. Results: ACDC gene molecular screening revealed the presence of previously described SNPs and a new nucleotide alteration, c.355T>G, leading to a protein variant, p.L119V. Measurement of serum concentration of Acpr30 demonstrated lower levels of Acpr30 in the obese population compared to controls (30.5 ± 28.3 vs. 43.9 ± 35.7 μg/ml, p < 0.01); in particular, significantly lower Acpr30 concentrations were observed in obese patients bearing c.–11377C>G SNP CG+GG genotypes than in those with CC genotype (22.9 ± 20.5 vs. 33.1 ± 29.4 μg/ml, p < 0.05). Conclusions: Our results confirmed that low serum levels of Acpr30 are related to severe obesity and a difference in protein expression is associated with variants in ACDC gene promoter region.

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“…Once the effect on waist-hip ratio is adjusted for, the effect on blood pressure remains significant, indicating that the effects are independent. A previous report 14 showed association between this same SNP and angiographic coronary artery disease in a prospective study of 402 men. The G allele was significantly associated with disease severity and future vascular events independent of serum adiponectin levels and traditional risk factors for cardiovascular disease.…”

Section: Discussionmentioning

confidence: 58%

“…10,13 Another study has shown this SNP to be associated with coronary stenosis and vascular events in men. 14 Thus there is a possible link between this SNP and cardiovascular disease. The G allele at rs266729 is associated with a reduction in adiponectin levels 10,15 and an increase in the incidence of coronary artery disease.…”

Section: Introductionmentioning

confidence: 99%

“…The G allele at rs266729 is associated with a reduction in adiponectin levels 10,15 and an increase in the incidence of coronary artery disease. 14 It has also been found that this allele leads to an increase in carotid intima media thickness, a measure of systemic atherosclerotic burden. 16 We have genotyped this SNP in a cohort of families ascertained for variability in blood pressure to ascertain whether there is an effect on blood pressure.…”

Section: Introductionmentioning

confidence: 99%

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Common variation in the adiponectin gene has an effect on systolic blood pressure

et al. 2011

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PO5-159 THE −11377 C>G PROMOTER VARIANT OF THE ADIPONECTIN GENE, PREVALENCE OF CORONARY ATHEROSCLEROSIS, AND INCIDENCE OF VASCULAR EVENTS IN MEN

Cited by 4 publications

References 0 publications

Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

Association of genetic variants in the adiponectin gene with adiponectin level and hypertension in Hong Kong Chinese

Molecular Analysis of the Adiponectin Gene in Severely Obese Patients from Southern Italy

Common variation in the adiponectin gene has an effect on systolic blood pressure

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