Po9-211 Systemic Markers of Periodontitis and Inflammation in Combination Predict Incident CVD Events

Pussinen, P.J.; Tuomisto, Karolina; Jousilahti, Pekka; Havulinna, Aki S.; Sundvall, Jouko; Salomaa, Veikko

doi:10.1016/s1567-5688(07)71221-7

Cited by 2 publications

(2 citation statements)

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“…These inflammatory mediators are considered to be the link between oral inflammatory diseases and associated systemic conditions. Inflammatory loading from periodontal disease could contribute to the progression of cardiometabolic and autoimmune diseases which are driven by inflammatory mechanisms leading to oxidative stress-induced tissue and organ damage (Pussinen et al 2007b). The bidirectional relationship between periodontal disease and diabetes mellitus is well documented.…”

Section: Effects Of Stress On Inflammationmentioning

confidence: 99%

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

Soory¹,

El-Shinnawi²

2011

Acute Phase Proteins as Early Non-Specific Biomarkers of Human and Veterinary Diseases

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Section: Effects Of Stress On Inflammationmentioning

confidence: 99%

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

Soory¹,

El-Shinnawi²

2011

Acute Phase Proteins as Early Non-Specific Biomarkers of Human and Veterinary Diseases

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“…Lipopolysaccharide (LPS), a cell wall component of gram-negative bacteria, plays a major role in the inflammatory response following bacterial infection [2], as well as in the myocardial depression seen in adult patients with sepsis or severe gram-negative bacterial infection [3]. But, even though PG-LPS is widely accepted as a contributor to PD-induced systemic inflammation, and high anti-PG antibody levels were reported to be a risk factor for future CVD events in a cohort of middle-aged subjects [4], little is known about the precise relationship between PG-LPS and cardiac dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

Matsuo

Kawamura

Okita

et al. 2021

Preprint

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Oral infections, particularly periodontitis, are a well-established risk factor for cardiovascular diseases, although the molecular mechanisms involved remain elusive. The aims of the present study were to investigate the effects of lipopolysaccharide derived from Porphyromonas gingivalis (PG-LPS) on cardiac function in mice, and to elucidate the underlying mechanisms. Mice (C57BL/6) were injected with PG-LPS (0.8 mg/kg/day) with or without an inhibitor of Toll-like receptor 4 (TLR4) signaling (TAK-242, 0.8 mg/kg/day) for 4 weeks. Left ventricular ejection function was significantly decreased at 1 week (from 67 ± 0.5 to 58 ± 1.2 %) and remained low at 4 weeks (57 ± 1.0 %). The number of apoptotic myocytes was increased (approximately 7.4-fold), the area of fibrosis was increased (approximately 3.3-fold) and the number of 8-hydroxydeoxyguanosine-positive myocytes, a sensitive indicator of oxidative DNA damage, was increased (approximately 7.6-fold) at 4 weeks in the heart of PG-LPS treated mice. However, levels of various serum pro-inflammatory cytokines in PG-LPS-treated mice were similar to those in control mice. The impairment of cardiac function in PG-LPS-treated mice appears to involve activation of TLR4-NADPH oxidase (NOX) 4 signaling, leading to abundant production of reactive oxygen species and Ca 2+ leakage from sarcoplastic reticulumn induced by calmodulin kinase II (CaMKII)-mediated phosphorylation of phospholamban (at Thr-17) and ryanodine receptor 2 (at Ser-2448). Pharmacological inhibition of TLR4 with TAK-242 attenuated the changes in cardiac function in PG-LPS-treated mice. Our results indicate that TLR4-NOX4 signaling may be a new therapeutic target for treatment of cardiovascular diseases in patients with periodontitis.

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Po9-211 Systemic Markers of Periodontitis and Inflammation in Combination Predict Incident CVD Events

Cited by 2 publications

References 0 publications

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

Diagnostic Value of Acute Phase Proteins in Periodontal, Psychosomatic and Cardiometabolic Diseases: Response to Treatment

Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice

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