2022
DOI: 10.3389/fcvm.2022.1037500
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Pocket CLARITY enables distortion-mitigated cardiac microstructural tissue characterization of large-scale specimens

Abstract: Molecular phenotyping by imaging of intact tissues has been used to reveal 3D molecular and structural coherence in tissue samples using tissue clearing techniques. However, clearing and imaging of cardiac tissue remains challenging for large-scale (>100 mm3) specimens due to sample distortion. Thus, directly assessing tissue microstructural geometric properties confounded by distortion such as cardiac helicity has been limited. To combat sample distortion, we developed a passive CLARITY technique (Pock… Show more

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