Podocin Regulates the Nephrin-Nephrin Distance in the Glomerular Pore

Abstract

Entropic consideration is one of the most fundamental way of understanding a physical, biological or chemical mechanism of a process and how the process behaves and evolves over time. Protein aggregation is a very important phenomena because it deals with a wide variety of diseases such as ALS, Alzheimer's and Parkinson's. In this study we consider the protein aggregation as a growth over time as a non-equilibrium process. Using the Fokker-Planck equations we calculate the entropy production of protein aggregation. This entropy is very important in understanding the diseases mentioned and how we can detect these diseases in very early stages based on entropy production.