Podophyllin 10% and 25% in the treatment of ano-genital warts. A comparative double-blind study.

Simmons, P D

doi:10.1136/sti.57.3.208

Cited by 25 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These facts had to be considered by drawing conclusions. The results of the control group (57% cured after 3 months) are comparable to the results in the study of Simmons et al 5 They studied podophyllin 10% and 25% in the treatment of anogenital warts; the effectiveness of these treatments were 21.8 and 22.2% after three months, respectively. In regard to the numbers of treatments, the fine‐needle cryotherapy can be performed in fewer treatments than the control group (Table 1).…”

Section: Discussionsupporting

confidence: 80%

Cryotherapy in the Treatment of Condylomata Acuminata: A Controlled Study of 64 Patients

Damstra¹,

Vloten²

1991

The Journal of Dermatologic Surgery and Oncology

View full text Add to dashboard Cite

A clinical controlled study is presented for the treatment of condylomata acuminata with cryotherapy in 64 patients. Condylomata resolved in 83% within 4 weeks and 96% after 6 weeks by using cryotherapy. The results were significantly better compared with the control group of 70 patients (13% and 45% after 4 weeks and 6 weeks, respectively). Other therapeutic modalities are reviewed. Cryotherapy is an elegant and effective method for the treatment of condylomata acuminata without discomfort to the patient.

show abstract

Section: Discussionsupporting

confidence: 80%

Cryotherapy in the Treatment of Condylomata Acuminata: A Controlled Study of 64 Patients

Damstra¹,

Vloten²

1991

The Journal of Dermatologic Surgery and Oncology

View full text Add to dashboard Cite

show abstract

“…Each has been associated with local or systemic toxicity, treatment failure, and local recurrence of disease. Cytotoxic agents such as topical podophyllin in a 10 or 25% solution, topical trichloroacetic acid in a 50% solution, or 5 % 5-fluorouracil cream are perhaps the easiest to use but are accompanied by local tissue inflammation and a high recurrence rate [56][57][58]. They are not useful for intravaginal, cervical or intraurethral lesions or during pregnancy [56][57][58].…”

Section: Treatment Of Genital Hpv Infectionmentioning

confidence: 99%

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Benson

1987

Adv Contracept

View full text Add to dashboard Cite

Historical perspectiveBeginning in the late 15th century, genital warts, and in fact many unexplained genital lesions, were attributed to an outbreak of syphilis occurring in Europe during the time [1]. Gonorrhea was later proposed as an etiology of genital warts. It was not until the discovery of the gonococcus in 1879 that this was refuted. The then new theory proposed that warts resulted from genital irritation caused by secretions 'disordered through venery', and led to the coining of the term venereal warts [1]. The viral etiology of skin warts was recognized in 1949 and it was not until 20 years later that viral particles were demonstrated microscopically in genital and anal warts [1].Rubin, in 1910, while examining histologic specimens from patients, noted abnormal cellular morphologic changes in clinically normal appearing tissue [2]. He proposed the concept that not only tissue invasion but also intrinsic cellular morphology could be determinants of neoplastic transformation [2]. The significance of lesions that were not invasive but were morphologically abnormal was hotly debated over the ensuing two decades until the concept of carcinoma in situ was introduced by Broder in 1932 [3]. The perfection and widespread use of the Papanicolao u (Pap) smear established the importance of these early lesions on a mass scale. Structure and biology of human papillomavirusHuman papillomavirus (HPV), the etiologic agent of genital warts, is a nonenveloped DNA virus with an icosahedral capsid of 50-55 n in diameter containing 72 capsomeres [4]. The HPV genome exists in three forms within virions and infected cells: (1) a covalenfly closed circular supercoiled form; (2) an open circular form; and (3) a linear form [4]. All forms may exist as non-integrated plasmids in both benign and malignant lesions although DNA hybridization studies have also demonstrated integrated HPV genome within host cell nuclei. 103 Advances in Contraception. ISSN 0267-4874.

show abstract

“…Podophyllotoxin is more active than podophyllin (94% effective compared to 29%) with recurrences of 23 versus 38% [16]. Podophyllotoxin is sufficiently safe and effective that it can be patientadministered for the treatment of genital condyloma.…”

Section: Podophyllin and Podophyllotoxinmentioning

confidence: 97%

Treatment of Papillomavirus Infections: Recent Practice and Future Approaches

Cowsert

1994

Intervirology

View full text Add to dashboard Cite

Podophyllin 10% and 25% in the treatment of ano-genital warts. A comparative double-blind study.

Cited by 25 publications

References 7 publications

Cryotherapy in the Treatment of Condylomata Acuminata: A Controlled Study of 64 Patients

Cryotherapy in the Treatment of Condylomata Acuminata: A Controlled Study of 64 Patients

Cervical carcinoma as a sexually transmitted disease: human papillomavirus and its possible etiologic role

Treatment of Papillomavirus Infections: Recent Practice and Future Approaches

Contact Info

Product

Resources

About