Podophyllin in dermatology: Revisiting a historical drug

Singh, Ajeet; Choudhary, Ritul; Ganguly, Satyaki

doi:10.4103/idoj.idoj_225_21

Cited by 7 publications

(4 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24 Genital warts are commonly treated with podophyllin, a cytotoxic substance obtained from Podophyllum peltatum and Podophyllum hexandrum. 25 Human skin keratinocytes infected with the human papillomavirus are prevented from proliferating by podophyllin, 26 which inhibits mitotic activity in rapidly dividing cells by preventing the positioning of chromosomes on the spindle during metaphase of mitosis due to a mixture of antimitotic chemicals, of which podophyllotoxin is the primary component. 27 Previous studies with podophyllin treated patients showed low clearance rates of 37%-63% and high rates of recurrence (42%-60%).…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Halim

Ahmed²,

Eyada

2023

Int J STD AIDS

View full text Add to dashboard Cite

Background Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial. Aim To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts. Methods This study included 57 patients, divided randomly into two groups. Group (A): diphenylcyclopropenone ( n = 29). Group (B): podophyllin 25% ( n = 28). In group (A), sensitization was done with 2% diphenylcyclopropenone. Then, after 1 or 2 weeks, treatment started with a weekly application of diphenylcyclopropenone solutions ranging between 0.001 and 1% until clearance, or for a maximum of 10 sessions. In group (B), podophyllin 25% was applied weekly until clearance or for a maximum of 6 weeks. Results Higher clearance was achieved in group A, with 19 of 29 (65.5%) patients, than in group B, with 9 of 28 (32.1%) ( p-value = 0.004). Also, effectiveness increases with young age in group A. Shorter wart duration was associated with better response in both groups ( p-value = 0.005). No serious adverse effects occurred in either group. No recurrence was detected in group A, while seven patients (77.8%) had recurrence in group B after 1 year of follow up. Conclusion Diphenylcyclopropenone shows a higher success rate than podophyllin in treating genital warts and a lower recurrence rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Halim

Ahmed²,

Eyada

2023

Int J STD AIDS

View full text Add to dashboard Cite

show abstract

“…Podophyllin is a plant compound that causes cells to arrest in mitosis, leading to tissue necrosis. Podophyllum resin 10% to 25% in compound tincture of benzoin used to be the standard provider-administered therapy for genital warts [33].…”

Section: Preparation Of the Drug And The Placebomentioning

confidence: 99%

The Efficacy of Combined Olive Leaf and Curcumin Extract on Healing Human Papillomavirus: A Randomized Clinical Trial

Rad

Changaee

Toulabi

et al. 2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Genital warts are sexually transmitted diseases for which there is no definitive cure. This study aimed to determine the effect of the combination of olive leaf extract and curcumin on the number of lesions and the duration of recovery in patients with external anogenital warts. Methods. This study is a three-blind randomized controlled clinical trial conducted in 2020. In this study, women with external anogenital warts were enrolled by the consecutive nonprobability sampling method and then assigned by stratified block randomization to two groups: placebo (n = 28) and intervention (n = 26). In the intervention group, the combined olive leaf and curcumin extract was applied topically three times a day until recovery and up to 12 weeks. Routine treatment was administered to both groups in addition to the interventions. The number of warts, the duration of recovery, and the severity and duration of treatment side effects were assessed in all participants. Results. The results showed that the mean number of warts was significantly lower in the intervention group (5.65 ± 5.223) than in the placebo group (7.61 ± 5.245) from the fifth day of treatment onwards ( p = 0.027 ). The mean duration of recovery in days in the intervention group (14.73 ± 9.735)) was significantly less than the placebo group (34.25 ± 18.863) ( p = 0.001 ). In addition, there was no significant difference between the two groups in the frequency of drug side effects such as burning ( p = 0.083 ), redness ( p = 0.413 ), and itching ( p = 0.706 ). The intervention group experienced side effects for a shorter duration of time (1.50 ± 1.924) compared to the placebo group (4.93 ± 8.366) ( p = 0.043 ). Conclusion. The combined 10% olive leaf and curcumin extract can be effective in reducing the number of warts, duration of healing, and reducing the duration of complications in patients with external anogenital warts and is recommended as a complementary treatment for these patients. This trail is registered with IRCT20200509047350N1

show abstract

“…[12][13][14][15] Derived from the roots of the Mayapple plant (Podophyllum peltatum), podophyllum resin has historically been used in traditional medicine and is most commonly used in topical treatments for various skin conditions such as genital warts. 16,17 Podophyllum resin contains podophyllotoxin compounds with antiviral properties capable of inhibiting the growth of specific cells. 16 In the context of HIV/AIDS-related OHL, management not only focuses on addressing the underlying viral infection but also on optimizing immune function through antiretroviral therapy (ART).…”

Section: Introductionmentioning

confidence: 99%

“…16,17 Podophyllum resin contains podophyllotoxin compounds with antiviral properties capable of inhibiting the growth of specific cells. 16 In the context of HIV/AIDS-related OHL, management not only focuses on addressing the underlying viral infection but also on optimizing immune function through antiretroviral therapy (ART). 7 Routine identification of EBV in OHL after treatment aligns with the crucial tasks of monitoring viral activity to assess treatment effectiveness and the potential for recurrence.…”

Section: Introductionmentioning

confidence: 99%

Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study

Nobre,

Moura,

de Arruda

et al. 2024

Int J STD AIDS

View full text Add to dashboard Cite

Background This study evaluated the presence of Epstein-Barr virus type 1 (EBV-1) DNA in patients living with HIV, before and after three different topical therapy protocols for oral hairy leukoplakia (OHL). Methods The sample consisted of five patients treated with topical solution of 25% podophyllin resin; six with 25% podophyllin resin plus 5% acyclovir cream; and four with 25% podophyllin resin plus 1% penciclovir cream. DNA was extracted from OHL scrapings and amplified by the PCR using specific primers for EBV-1 (EBNA-1). Results Clinical healing of OHL lesions was observed across all treatment groups over time. At baseline, EBNA-1 was detected in all OHL lesions. After treatment, OHL samples from three patients treated with 25% podophyllin resin plus 5% acyclovir cream and from one patient treated with 25% podophyllin resin plus 1% penciclovir cream exhibited negative EBNA-1 viral gene encoding. Despite the clinical resolution of OHL, 11 patients (73.3%) showed EBNA-1 positivity immediately after the lesion disappeared. Three patients (20%) treated with podophyllin resin displayed both EBNA-1 positivity and a recurrence of OHL, in contrast to no recurrence in the other two groups. Conclusions These findings suggest potential associations between treatment formulations, EBNA-1 persistence, and the recurrence of OHL lesions.

show abstract

Podophyllin in dermatology: Revisiting a historical drug

Cited by 7 publications

References 40 publications

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

The Efficacy of Combined Olive Leaf and Curcumin Extract on Healing Human Papillomavirus: A Randomized Clinical Trial

Identification of Epstein-Barr virus after topical treatment for oral hairy leukoplakia: A preliminary study

Contact Info

Product

Resources

About