2021
DOI: 10.3389/fcell.2021.672590
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Podophyllotoxin Exposure Affects Organelle Distribution and Functions in Mouse Oocyte Meiosis

Abstract: Podophyllotoxin (POD) is one of the most characterized lignans that is commonly found in podophyllum, and its preparations and derivatives are widely used in clinical treatment due to strong antitumor and antivirus activities. POD has been reported for its neurotoxicity, liver toxicity, and potential reproductive toxicity. In the present study, we investigated the effects of POD on the organelles of mouse oocytes during meiosis. Our results showed that exposure to POD significantly reduced the developmental co… Show more

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Cited by 3 publications
(5 citation statements)
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References 54 publications
(68 reference statements)
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“…In contrast, following PPT incubation, the ER underwent significant changes, manifested as dilation of the ER cisternae, which was observed at 24 h and progressed further at 48 h. Vacuole formation likely represented extreme dilation of ER cisternae. Those morphological changes were consistent with ER stress, pointing towards the possible involvement of this mechanism in the initiation of programmed cell death in those cells, similar to previous reports [ 15 , 37 , 38 ]. ER stress is characterized by the accumulation of unfolded and/or misfolded proteins within the ER lumen, a process that can be triggered by the expression of abnormal proteins, proteasome inhibition, nutrient deficiency, hypoxia, calcium depletion, and other conditions.…”
Section: Discussionsupporting
confidence: 92%
“…In contrast, following PPT incubation, the ER underwent significant changes, manifested as dilation of the ER cisternae, which was observed at 24 h and progressed further at 48 h. Vacuole formation likely represented extreme dilation of ER cisternae. Those morphological changes were consistent with ER stress, pointing towards the possible involvement of this mechanism in the initiation of programmed cell death in those cells, similar to previous reports [ 15 , 37 , 38 ]. ER stress is characterized by the accumulation of unfolded and/or misfolded proteins within the ER lumen, a process that can be triggered by the expression of abnormal proteins, proteasome inhibition, nutrient deficiency, hypoxia, calcium depletion, and other conditions.…”
Section: Discussionsupporting
confidence: 92%
“…For example, exposure to zearalenone leads to the abnormal distribution of the Golgi apparatus in porcine oocytes, which causes the decrease in the maturation rate of porcine oocytes and affects the quality of porcine oocytes ( Wang et al, 2021 ). Podophyllotoxin can cause the Golgi apparatus fragment of mouse oocytes and vesicle transport defects, thus causing the meiosis failure of mouse oocytes ( Lu et al, 2021 ). Lysosomes are round organelles formed by a monolayer covering various acid hydrolases ( Lie and Nixon, 2018 ), which mainly participate in the metabolic activities of various substances in cells ( Albanese et al, 2019 ).…”
Section: Discussionmentioning
confidence: 99%
“…As described in Figure 2, cleisindosides A (3), cleisindosides B (4), cleisindosides C (5), cleisindosides D (6), cleisindosides E (7), cleisindosides F (8), picroburseranin (9) and 7-hydroxypicropolygamain (10) were isolated from the fruits of Cleistanthus indochinensis. Among them, compounds 5, 9 and 10 were highly cytotoxic to oral epidermoid carcinoma KB cells with IC 50 values of 7.5, 0.062, and 10.8 μM, respectively.…”
Section: Cleistanthus Genusmentioning
confidence: 97%
“…[9] In addition, PPT was toxic to mouse oocyte organelles by affecting its meiosis. [10] Previously, we reported total synthesis, biotransformation, structural modifications, and bioactivities of PPT and its derivatives until 2015. Additionally, the isolation of new PPT analogues from plants was summarized by September 2014.…”
Section: Introductionmentioning
confidence: 99%
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