Podoplanin, E‐cadherin, β‐catenin, and <scp>CD</scp>44v6 in recurrent ameloblastoma: their distribution patterns and relevance

Siar, Chong Huat; Ishak, Ismadi; Ng, Kok Han

doi:10.1111/jop.12203

Cited by 22 publications

(28 citation statements)

References 36 publications

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“…Moreover, as a sign of active EMT, we found an increased cytoplasmic reactivity for vimentin and a prevailing nuclear Twist 1 and Slug 1 expression in tumor cells, especially at the tumor’s advancing edge. Our results were confirmed in the literature by cases of ameloblastomas, where it was also been noticed an E-cadherin downregulation simultaneously with an upregulation of podoplanin, β-catenin, and CD44v6 at the tumor advancing edges, suggesting their involvement in mediating collective cell migration and local invasiveness [29]. Moreover, it has been reported that transcription factors such as Snail, Slug, SIP1, and Twist could have differential roles in mediating local invasiveness in ameloblastomas [30].…”

Section: Discussionsupporting

confidence: 87%

“…Also, in the present study we have observed a podoplanin expression at the advancing edge, mainly at the periphery of tumor proliferations, suggesting its involvement in tumor invasiveness. In fact, it is well known that this transmembrane sialomucin is involved in odontogenesis and in promoting local invasion of various odontogenic tumors [29]. …”

Section: Discussionmentioning

confidence: 99%

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Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

et al. 2016

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BackgroundCalcifying epithelial odontogenic tumor (CEOT) is a rare benign neoplasia, locally aggressive, that tends to invade bone and adjacent soft tissues. This case report describes the thirteenth known case of CEOT with maxillary sinus extension and the second one that also involves the buccal vestibule mucosa with peculiar histopathological and immunohistochemical data.Case presentationHere we report the case of a 45-year-old female with a CEOT diagnosed and treated at the Oral & Maxillofacial Surgery Department, County Clinical Emergency Hospital of Craiova, Romania. The clinical and imaging investigation revealed an intraosseous tumor developed from the left posterior maxilla with maxillary sinus and buccal vestibule mucosa extension. Histopathology found an epithelium-rich CEOT variant, but with scattered S100 positive clear cells, focal small rounded cementum-like deposits and areas with some degree of nuclear pleomorphism. The immunohistochemical investigations emphasised its local aggressiveness behavior with involvement of multiple molecular mechanisms that underlie tumor invasiveness. A subtotal maxillectomy was performed followed by defect reconstruction.ConclusionsWe discuss the relevant clinicopathological features of an aggressive rare case of CEOT with maxillary sinus extension and buccal vestibule mucosa involvement. The immunohistochemical study suggests its utility in attempting to assess the degree of local tumor aggressiveness and thus in adopting the most efficient therapeutic attitude.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

et al. 2016

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“…In the current investigation, a few connective tissue cells were weakly positive for podoplanin in a limited number of cases. The lack of podoplanin immunostaining in ectomesenchymal elements of AF and OM and fibrous wall of COC and the “variable” podoplanin expression in ameloblastoma‐fibroblasts has also been reported previously. Further research is required to clarify this issue.…”

Section: Discussionsupporting

confidence: 74%

Is podoplanin expression associated with transforming growth factor‐β signaling in odontogenic cysts and tumors?

Etemad‐Moghadam

Alaeddini

2018

J Oral Pathology Medicine

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“…Canonical Wnt ligands (Wnt-1, 2, 3, 8a, 8b, 10a, and 10b) were reported to be expressed in 100% of ameloblastomas (n=72) representing unicystic, solid/multicystic, and desmoplastic subtypes, and including 10 cases of recurrent ameloblastoma (Siar 2012). The expression of β-catenin, the signal transducer of canonical Wnt signaling, is inconsistently reported, with expression detected by immunohistochemistry in 15–100% of ameloblastomas [62–69]. Overall, 82% of ameloblastomas express β-catenin (n=137).…”

Section: Wntmentioning

confidence: 99%

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

Amm

MacDougall

2016

Curr Oral Health Rep

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Several molecular pathways have been shown to play critical roles in the pathogenesis of odontogenic tumors. These neoplasms arise from the epithelial or mesenchymal cells of the dental apparatus in the jaw or oral mucosa. Next generation genomic sequencing has identified gene mutations or single nucleotide polymorphisms associated with many of these tumors. In this review, we focus on two of the most common odontogenic tumor subtypes: ameloblastoma and keratocystic odontogenic tumors. We highlight gene expression and protein immunohistological findings and known genetic alterations in the hedgehog, BRAF/Ras/MAPK, epidermal growth factor receptor, Wnt and Akt signaling pathways relevant to these tumors. These various pathways are explored to potentially target odontogenic tumors cells and prevent growth and recurrence of disease. Through an understanding of these signaling pathways and their crosstalk, molecular diagnostics may emerge as well as the ability to exploit identified molecular differences to develop novel molecular therapeutics for the treatment of odontogenic tumors.

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Podoplanin, E‐cadherin, β‐catenin, and CD44v6 in recurrent ameloblastoma: their distribution patterns and relevance

Cited by 22 publications

References 36 publications

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

Maxillary calcifying epithelial odontogenic tumor with sinus and buccal vestibule extension: a case report and immunohistochemical study

Is podoplanin expression associated with transforming growth factor‐β signaling in odontogenic cysts and tumors?

Molecular Signaling in Benign Odontogenic Neoplasia Pathogenesis

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