Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines

Inoue, Harumi; Miyazaki, Yuji; Kikuchi, Kentaro; Yoshida, Noriaki; Ide, Fumio; Ohmori, Yoshihiro; Tomomura, Akihito; Sakashita, Hideaki; Kusama, Kaoru

doi:10.2334/josnusd.54.241

Cited by 30 publications

(29 citation statements)

References 38 publications

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“…Cytoskeleton remodeling is often associated with epithelial to mesenchymal transition, although podoplanin can also stimulate tumor invasion in the absence of epithelial to mesenchymal transition . Moreover, podoplanin highly influences the expression of matrix metalloproteinase‐9, which is believed to play a key role in processes requiring basal membrane disruption, such as tumor invasion . Recent experimental data also demonstrated that the epidermal growth factor and the transforming growth‐factor beta promote podoplanin expression in oral squamous cell carcinoma .…”

Section: Discussionmentioning

confidence: 90%

“…Moreover, podoplanin highly influences the expression of matrix metalloproteinase‐9, which is believed to play a key role in processes requiring basal membrane disruption, such as tumor invasion . Recent experimental data also demonstrated that the epidermal growth factor and the transforming growth‐factor beta promote podoplanin expression in oral squamous cell carcinoma . The phenotypic effects of transforming growth‐factor beta expression in advanced cancer stages include the induction of epithelial to mesenchymal transition and the activation of cancer‐associated fibroblasts together with the promotion of an intense fibrotic remodeling of the extracellular matrix .…”

Section: Discussionmentioning

confidence: 99%

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Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis

Mermod

Bongiovanni

Petrova³

et al. 2016

Head & Neck

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis

Mermod

Bongiovanni

Petrova³

et al. 2016

Head & Neck

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“…Other studies concerning astrocytic and gastric carcinomas, lung squamous cancer and other malignancies, have demonstrated the involvement of podoplanin in cell migratory activity necessary for metastasis [18], [60], [61]. Furthermore, it has been proposed that podoplanin might serve as a potential clinical marker for the malignant progression of oral leukoplakia [62], and it is regarded as a novel myoepithelial marker in salivary gland tumors [63].…”

Section: Discussionmentioning

confidence: 99%

The Role of Podoplanin in the Biology of Differentiated Thyroid Cancers

et al. 2014

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Podoplanin (PDPN), a mucin-type transmembrane glycoprotein specific to the lymphatic system is expressed in a variety of human cancers, and is regarded as a factor promoting tumor progression. The purpose of this study was to elucidate the molecular role of PDPN in the biology of thyroid cancer cells. PDPN expression was evaluated in primary thyroid carcinomas and thyroid carcinoma cell lines by RT-qPCR, Western blotting, IF and IHC. To examine the role of podoplanin in determining a cell's malignant potential (cellular migration, invasion, proliferation, adhesion, motility, apoptosis), a thyroid cancer cell line with silenced PDPN expression was used. We observed that PDPN was solely expressed in the cancer cells of 40% of papillary thyroid carcinoma (PTC) tissues. Moreover, PDPN mRNA and protein were highly expressed in PTC-derived TPC1 and BcPAP cell lines but were not detected in follicular thyroid cancer derived cell lines. PDPN knock-down significantly decreased cellular invasion, and modestly reduced cell migration, while proliferation and adhesion were not affected. Our results demonstrate that PDPN mediates the invasive properties of cells derived from papillary thyroid carcinomas, suggesting that podoplanin might promote PTC progression.

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“…Emerging evidence indicates that MMPs can stimulate processes associated with uPA and uPAR to enhance the tumor growth, invasion, and metastatic potential [33]. Most reports have suggested that the predominant protein expression of MMP-2 and MMP-9 is correlated with a poor prognosis [34].…”

Section: Inhibitory Effects Of β-Elemene On Tumor Growthmentioning

confidence: 98%

Inhibition of tumor growth by β-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model

Hong

Liu

et al. 2015

Melanoma Research

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This paper explores the underlying mechanism through which β-elemene inhibits the growth of intraocular melanoma in a mouse model. C57BL/6J mice were administered a subretinal injection of B16F10 melanoma cells and divided into two groups: treatment and control. The treatment group was administered β-elemene through an intravitreal injection and the control group was injected with a blank emulsion. After 21 days of continuous treatment, tumor masses were removed and weighed. The mRNA expression levels of the urokinase-type plasminogen activator (uPA), uPA receptor (uPAR), matrix metalloproteinase (MMP)-2, and MMP-9 were assayed by real-time PCR, and the protein expression levels of uPA, uPAR, MMP-2, and MMP-9 were assayed by immunocytochemistry and western blotting. Tumor size was inhibited by β-elemene in the treatment group, and the expressions of uPA, uPAR, MMP-2, and MMP-9 were all downregulated at both the mRNA and the protein level compared with the control group. In a mouse model of intraocular melanoma, β-elemene inhibits tumor growth by downregulating the expression of uPA, uPAR, MMP-2, and MMP-9.

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Podoplanin promotes cell migration via the EGF-Src-Cas pathway in oral squamous cell carcinoma cell lines

Cited by 30 publications

References 38 publications

Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis

Correlation between podoplanin expression and extracapsular spread in squamous cell carcinoma of the oral cavity using subjective immunoreactivity scores and semiquantitative image analysis

The Role of Podoplanin in the Biology of Differentiated Thyroid Cancers

Inhibition of tumor growth by β-elemene through downregulation of the expression of uPA, uPAR, MMP-2, and MMP-9 in a murine intraocular melanoma model

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