Point-and-shoot: rapid quantitative detection methods for on-site food fraud analysis – moving out of the laboratory and into the food supply chain

Ellis, David I.; Muhamadali, Howbeer; Haughey, Simon A.; Elliott, Christopher T.; Goodacre, Royston

doi:10.1039/c5ay02048d

Cited by 199 publications

(138 citation statements)

References 125 publications

(131 reference statements)

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“…(c) Combination of Raman spectroscopy with other techniques for chemical identification in “hyphenated” instruments (sometimes called also combined or hybrid systems). The integration of more technologies in one device, favored by the miniaturization of the equipment, would offer the possibility of a more complete (more rapid and/or with a greater confidence on the response) analysis of the sample of interest; for example, FTIR‐Raman analyzers are already available . (d) Development of Raman equipment capable of working efficiently in spectral regions in which the contribution from fluorescence and photobleaching are minimized, for example, with excitation at 1,064 nm or higher.…”

Section: Discussion and Perspectivesmentioning

confidence: 99%

“…From the graph, one can notice that the number of publications in which portable Raman instruments are used for SERS detection has been significantly growing in the last 5–10 years. To the best of our knowledge, although a large number of articles and reviews have been published, also in recent years, on food, drugs and medicine, explosives and warfare, environment, and art preservation, no paper has been specifically dedicated to the use of portable instruments for the detection of these analytes. Aim of this review is to fill this gap, focusing on the SERS detection of food contaminants.…”

Section: Introductionmentioning

confidence: 99%

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SERS detection of food contaminants by means of portable Raman instruments

Pilot

2018

J Raman Spectroscopy

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Surface‐enhanced Raman scattering (SERS) has been emerging as a powerful tool for the detection of a variety of analytes due to its very high sensitivity and fingerprinting recognition capabilities. Technological progresses in the equipment for Raman analysis are contributing to its transition from a technically demanding research method to a more widely available analytical technique. In particular, the commercialization of portable or handheld instruments has opened up the possibility of performing in situ analysis. In this review, a selection of the SERS substrates that are expected to be more suitable for use in combination with portable instruments is presented: Substrates are compared, for example, in terms of performance, reproducibility, ease of fabrication, and surface area. Moreover, this paper provides a survey of the current diffusion of portable Raman instruments in the SERS detection of food contaminants: The investigation of several analytes is summarized (mainly toxins, virus, bacteria, pesticides, forbidden food dyes, and preservatives), reporting on the limits of detection and on the eventual coupling with concentration or separation techniques. A brief perspective on possible future developments of the SERS detection with portable instruments is also provided.

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Section: Discussion and Perspectivesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

SERS detection of food contaminants by means of portable Raman instruments

Pilot

2018

J Raman Spectroscopy

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“…Additional benchmarking involved repeat biotransformations conducted over several weeks and this established the excellent reproducibility and robustness of this new analytical approach. In conclusion, we believe that additional optimisation and configuration of the UVRR instrument set‐up will make this approach amenable to miniaturization and in situ point‐and‐shoot analyses, thus enhancing the potential for wider application. The method could also be developed as a high‐throughput screening technique for enzyme activity, including the monitoring of cascade biotransformations, as well as for investigating enzyme inhibitors.…”

Section: Figurementioning

confidence: 99%

Real‐Time Monitoring of Enzyme‐Catalysed Reactions using Deep UV Resonance Raman Spectroscopy

Westley

Fisk

et al. 2017

Chemistry A European J

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For enzyme‐catalysed biotransformations, continuous in situ detection methods minimise the need for sample manipulation, ultimately leading to more accurate real‐time kinetic determinations of substrate(s) and product(s). We have established for the first time an on‐line, real‐time quantitative approach to monitor simultaneously multiple biotransformations based on UV resonance Raman (UVRR) spectroscopy. To exemplify the generality and versatility of this approach, multiple substrates and enzyme systems were used involving nitrile hydratase (NHase) and xanthine oxidase (XO), both of which are of industrial and biological significance, and incorporate multistep enzymatic conversions. Multivariate data analysis of the UVRR spectra, involving multivariate curve resolution‐alternating least squares (MCR‐ALS), was employed to effect absolute quantification of substrate(s) and product(s); repeated benchmarking of UVRR combined with MCR‐ALS by HPLC confirmed excellent reproducibility.

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“…Currently, benchtop SORS spectrometers are located in several international airports for the detection of liquid explosives . Handheld Raman spectrometers have attracted increasing interest in recent years, namely, due to their ease of use and portability, with many portable Raman instruments being available on the market . Here, we present a non‐destructive way of obtaining Raman spectra through plastic using handheld spectrometers, thus demonstrating the use of Raman spectroscopy in the field for customs and defence applications.…”

Section: Introductionmentioning

confidence: 95%

“…The SORS technique has also been demonstrated at a laser excitation of 1,064 nm where the advantage of a longer wavelength to overcome fluorescence issues, associated with the presence of glass barriers, was discussed . Handheld CR with a 1,064‐nm laser excitation has also been used for the assessment of packaged food substances susceptible to food fraud including saffron and beef …”

Section: Introductionmentioning

confidence: 99%

Through barrier detection of ethanol using handheld Raman spectroscopy—Conventional Raman versus spatially offset Raman spectroscopy (SORS)

Nicolson

Jamieson

Mabbott

et al. 2017

J Raman Spectroscopy

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Spatially offset Raman spectroscopy (SORS) provides chemical analysis at depth even when obscuring barriers such as plastic or tissue are present. As the collection probe is moved further away from the point of laser excitation, scattered photons from deeper layers begin to dominate the acquired spectra, thus giving rise to through barrier detection. Here, we demonstrate the potential of conventional Raman (CR) and SORS for through barrier detection using handheld spectrometers. We report the collection of Raman signals from an ethanol solution through plastic at thicknesses of up to 21 mm using SORS in combination with multivariate analysis. SORS is compared to CR, where we also demonstrate impressive through barrier detection of ethanol at depths up to 9 mm. We also highlight the advantage of applying multivariate analysis for through barrier detection using CR or SORS, particularly when peaks with similar spectral features are present in both the barrier and analyte spectra. In addition, to the best of our knowledge, this is the first report of the assessment of the maximum level of through barrier detection using handheld CR and SORS instruments with a backscattering geometry.

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Point-and-shoot: rapid quantitative detection methods for on-site food fraud analysis – moving out of the laboratory and into the food supply chain

Abstract: Major food adulteration and contamination events occur with alarming regularity and are known to be episodic, with the question being not if but when another large-scale food safety/integrity incident will occur.

Cited by 199 publications

References 125 publications

SERS detection of food contaminants by means of portable Raman instruments

SERS detection of food contaminants by means of portable Raman instruments

Real‐Time Monitoring of Enzyme‐Catalysed Reactions using Deep UV Resonance Raman Spectroscopy

Through barrier detection of ethanol using handheld Raman spectroscopy—Conventional Raman versus spatially offset Raman spectroscopy (SORS)

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