We show that Fano interference explains how point contact spectroscopy in heavy-electron materials probes the emergence of the Kondo heavy-electron liquid below the same characteristic temperature T ء as that seen in many other experiments and why the resulting measured conductance asymmetry reflects the universal Kondo liquid behavior seen in these. Its physical origin is the opening of a new channel for electron tunneling beyond that available from the background conduction electrons. We derive the Fano formula with a mean-field slave boson approach for the Kondo lattice model and generalize it to finite temperature and realistic situation by introducing empirical parameters. The resulting simple expression for the Fano interference provides a good fit to the experimental results for CeCoIn 5 , CeRhIn 5 , and YbAl 3 , over the entire range of bias voltages, and deduce a lifetime of the heavy quasiparticle excitations that agrees well with recent state-of-the-art numerical calculations.Heavy-electron materials have a rich phase diagram showing a competition between antiferromagnetism and unconventional superconductivity and quantum critical behavior. Although the underlying physics responsible for this competition is still unclear, it appears to be primarily associated with the heavy electron, or Kondo liquid, that emerges from the collective hybridization of light conduction electrons with the local f moments. 1-4 Understanding the nature and consequence of this hybridization is therefore a central task in the field of heavy-electron physics.Point contact spectroscopy ͑PCS͒ ͑Ref. 5͒ probes the lowenergy collective excitations ͑such as phonons͒ and may be expected to provide important information for our understanding of the low-energy physics of heavy-electron materials. For superconductors, PCS provides a quantitative measure of the Andreev reflection and helps determine the superconducting order parameters and the paring mechanism. 6 Especially, a universal asymmetry has been observed in the point contact tunneling experiments of high-T C superconductors, 7 in contrast to what is expected for Bardeen-Cooper-Schrieffer-type superconductors.For decades, a similar conductance asymmetry has also been observed in many heavy-electron materials such as CeCu 6 ͑Ref. 8͒ and URu 2 Si 2 ͑Ref. 9͒ but its origin has not been understood. For example, the fact that the asymmetry is practically independent of the material of the metallic tips suggests that it is intrinsic and excludes previous explanations based on self-heating effects. 10 On the other hand, the usual tunneling model requires an unrealistic background density of states ͑DOS͒ to explain the experimental data. In CeCoIn 5 , the DOS derived from it has a broad maximum below the Fermi energy, 11 in contradiction with the theoretical expectations and numerical calculations that show a sharp quasiparticle peak developing at low temperatures well above the Fermi energy.An essential clue to the underlying physics comes from two recent observations concerning the p...