»Point-of-Care« D-Dimer Testing

Antović, Jovan P.

doi:10.2478/v10011-010-0032-9

Cited by 4 publications

(4 citation statements)

References 38 publications

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“…The main potential problem with POC assays is inadequate quality control since assays are most commonly performed by personnel without laboratory training and knowledge of quality control procedures, while assays commonly use whole blood and such samples for quality control are not available. Clinicians need to be aware of those issues 54,55 .…”

Section: Point Of Care (Poc) D-dimer Testingmentioning

confidence: 99%

D-dimer: A laboratory point of view

Antović¹

2013

Srce i krvni sudovi

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Section: Point Of Care (Poc) D-dimer Testingmentioning

confidence: 99%

D-dimer: A laboratory point of view

Antović¹

2013

Srce i krvni sudovi

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“…High D‐Dimer occurs in many conditions including dirofilariasis, 3 hepatic disease, 4 sepsis, 5 hemoabdomen, 4 neoplasia, 6 and immune‐mediated hemolytic anemia (IMHA) 7 in dogs, and septic joint disease, 8 colic, 9 , 10 , 11 and endurance exercise 12 in horses, thus has poor specificity for clinical thrombosis. 13 Conversely, high D‐dimer is highly sensitive for thrombosis, and so the primary clinical utility is exclusion of thrombotic syndromes including deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE). 14 In dogs, D‐dimer is considered the marker of choice for the exclusion of PTE.…”

Section: Introductionmentioning

confidence: 99%

Immunoreactivity of canine, feline, and equine D‐dimer with antibodies to human D‐dimer

Brown,

Noormohammadi,

Courtman

2023

Veterinary Internal Medicne

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BackgroundCommercially available D‐dimer assays use antibodies against human D‐dimer, with limited sensitivity and specificity data in companion animals.ObjectivesTo evaluate the immunoreactivity of D‐dimer in plasma of dogs, horses, and cats with commercially available antibodies to human D‐dimer.AnimalsPlasma samples were collected from healthy dogs and horses, and from surplus feline plasma submitted for diagnostic purposes.MethodsDescriptive research study. A cross‐linked fibrin lysate was prepared from plasma samples, and SDS‐PAGE and immunoblotting were performed with a variety of commercially available antibodies to human D‐dimer.ResultsThe selected antibodies demonstrated variable reactivity with D‐dimer of each species. The monoclonal antibody DD44 bound canine D‐dimer with good specificity and sensitivity, but this antibody did not react with feline or equine D‐dimer. The polyclonal antibody D2D bound putative D‐dimer in dogs, cats, and horses with good specificity, and higher sensitivity compared to human D‐dimer.Conclusions and Clinical ImportanceThe variable performance of commercially available human D‐dimer assays between species is, in part, because of inter‐species variation in D‐dimer immunoreactivity. The use of these assays should follow validation studies. Monoclonal antibody DD44 could be a focus for the development of a canine‐specific assay.

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“…Platelet numbers are mildly decreased and subclinical prolongation is observed in coagulation tests along with a picture of DIC characterized by systemic intravascular fibrin deposition, micro vascular dysfunction, bleedings and organ failures (9). Low platelet count, low fibrinogen levels, in crea sed fibrin degradation products including D-dimer and prolongation of coagulation tests are used in establishing a diagnosis of DIC in cases of thrombosis and/or bleeding and/or multiorgan failure (3,10). DIC has a complex pathogenesis which has been reported to include the induction of intravascular platelet activation secondary to thrombin formation (7).…”

Section: Introductionmentioning

confidence: 99%

“…There are studies in the literature indicating a relationship between poor prognosis and thrombocytopenia, and impaired platelet functioning in patients in the intensive care unit (12,13). Platelet number and indices have been reported as good predictors of 28-days mortality in patients with DIC (10).…”

Section: Introductionmentioning

confidence: 99%

Thrombocyte and Erythrocyte Indices in Sepsis and Disseminated Intravascular Coagulation

Açıkgöz¹,

Akduman²,

Eskici³

et al. 2012

Journal of Medical Biochemistry

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Thrombocyte and Erythrocyte Indices in Sepsis and Disseminated Intravascular CoagulationSepsis is the inflammatory response against infection. The existence of DIC during sepsis indicates a poor prognosis and coagulation abnormalities and thrombocytopenia may exist. The aim of this study was to investigate platelet and erythrocyte indices in sepsis patients with DIC and without DIC. In both groups coagulation tests, platelet count and indices, erythrocyte count and indices were retrospectively analysed. In the sepsis plus DIC patients the prothrombin time and D-dimer values were found significantly higher and fibrinogen, platelet and plateletcrit were found significantly lower than in the sepsis without DIC group. The analysis of mean platelet volume, platelet distribution width, erythrocyte count and indices revealed no significant differences between the two groups. These results showed us that the depression of bone marrow in septic patients with DIC and without DIC did not differ. The activation of the coagulation system might probably be the cause of thrombocyte depletion in DIC.

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»Point-of-Care« D-Dimer Testing

Cited by 4 publications

References 38 publications

D-dimer: A laboratory point of view

D-dimer: A laboratory point of view

Immunoreactivity of canine, feline, and equine D‐dimer with antibodies to human D‐dimer

Thrombocyte and Erythrocyte Indices in Sepsis and Disseminated Intravascular Coagulation

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