Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods

Suleman, Shariq; Shukla, Sudheesh K.; Malhotra, Nitesh; Bukkitgar, Shikandar D.; Shetti, Nagaraj P.; Pilloton, Roberto; Narang, Jagriti; Tan, Yen Nee; Aminabhavi, Tejraj M.

doi:10.1016/j.cej.2021.128759

Cited by 117 publications

(89 citation statements)

References 85 publications

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“…Moreover, in that case, the most effective control strategy is to apply strict SDPs (Strategy 4). To ensure the SDPs properly, the government can introduce a mobile network GPS tracking system [ 22 , 23 ] through which infected individuals can be taken into strict surveillance more effectively. Applying this procedure, Hong Kong already has obtained magnificent outcomes [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Efficacy of limited antiviral treatment, testing, hospitalization, and social distancing for COVID-19 pandemic

Hasan¹,

Ahmed²,

Urmy³

2021

Sensors International

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The control measures of a pandemic must be cautiously evaluated, especially when resources are “limited”. A model of COVID-19 transmission dynamics is applied to assess the impact of antiviral treatment, testing, hospitalization, and social distancing. Under the assumption of “unlimited” resources, five control strategies involving social distancing, testing, hospitalization, and antiviral treatment are tested. Then these “optimal” policies are sought in the case of limited resources on behalf of a COVID-19 pandemic scenario. The amplitude of peak epidemics will often be minimized by executing strategies from the beginning of a pandemic, spreading the epidemics’ greatest impact over a longer time frame. Therefore, the timing and potency of control measures can reduce the pressure on the system during the top of the epidemic through the pandemic, decreasing the pressure on the healthcare infrastructure. In case of limited access to antiviral supplies, the role of testing, hospitalization, and social distancing strategies is emphasized in this study.

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Section: Resultsmentioning

confidence: 99%

Efficacy of limited antiviral treatment, testing, hospitalization, and social distancing for COVID-19 pandemic

Hasan¹,

Ahmed²,

Urmy³

2021

Sensors International

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“…This comprehensive review article focuses on the most recent advances in POC diagnostic devices for potential diagnosis of COVID-19 that meet ASSURED criteria, which is distinct from previous review papers where nanomaterial-based biosensors [ 30 – 33 ] and non-POC diagnostic techniques [ 34 – 44 ] were summarized. In addition, the commercial POC biosensors have not been critically reviewed [ 45 – 48 ]. In this review, the development of POC biosensors for the detection of proteins and viral nucleic acids for COVID-19 is comprehensively reviewed based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors, providing a comprehensive survey with regard to their usability and performance.…”

Section: Introductionmentioning

confidence: 99%

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Rasmi

Khan

et al. 2021

Anal Bioanal Chem

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Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections.

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“…The development of a promising theranostic agent, which is safe and natural medicine with diagnostic capability, might be advantageous [ 14 , 15 , 16 ]. Over the last decade, different biosensing platforms accompanied by functional materials have been developed for various infectious and non-infectious diseases [ 9 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Among different functional materials, carbon dots (CDs) have gained enormous scientific attention in view of their unique physiochemical properties.…”

Section: Introductionmentioning

confidence: 99%

Allium sativum derived carbon dots as a potential theranostic agent to combat the COVID-19 crisis

Kalkal

Allawadhi

Pradhan

et al. 2021

Sensors International

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Coronavirus disease 2019 (COVID-19) is one of the worst pandemics to have hit humanity. The manifestations are quite varied, ranging from severe lung infections to being asymptomatic. Hence, there is an urgent need to champion new tools to accelerate the end of this pandemic. Compromised immunity is a primary feature of COVID-19. Allium sativum (AS) is an effective dietary supplement known for its immune-modulatory, antibacterial, anti-inflammatory, anticancer, antifungal, and anti-viral properties. In this paper, it is hypothesized that carbon dots derived from AS (AS-CDs) may possess the potential to downgrade the expression of pro-inflammatory cytokines and revert the immunological aberrations to normal in the case of COVID-19. Carbon dots (CDs) have already been explored in the world of nanobiomedicine as promising theranostic candidates for bioimaging and drug/gene delivery. The antifibrotic and antioxidant effects of AS are elaborated, as demonstrated in several studies. It is found that the most active constituent of AS, allicin has a highly potent antioxidant and reactive oxygen species (ROS) scavenging effect. The antibacterial, antifungal, and anti-viral effects along with their capability of negating inflammatory effects and cytokine storm, are discussed. The synthesis of theranostic CDs from AS may provide a novel weapon in the therapeutic armamentarium for the management of COVID-19 infection and, at the same time, could act as a diagnostic agent for COVID-19.

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Point of care detection of COVID-19: Advancement in biosensing and diagnostic methods

Cited by 117 publications

References 85 publications

Efficacy of limited antiviral treatment, testing, hospitalization, and social distancing for COVID-19 pandemic

Efficacy of limited antiviral treatment, testing, hospitalization, and social distancing for COVID-19 pandemic

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Allium sativum derived carbon dots as a potential theranostic agent to combat the COVID-19 crisis

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