Point-of-care devices for the detection of biomarkers of periprosthetic joint infection: State of the art and future perspectives

Functionalized orthopaedic implant as pH electrochemical sensing tool for smart diagnosis of hardware infection

“…In the overall scenario of implantable devices for infection monitoring, few examples have been reported in the literature based on electrochemical or optical detection. 15 An interesting example of the first approach has been reported by Tomšík et al , which developed a potentiometric pH sensor based on polyaniline for pH measurement in synovial fluid by depositing chemically the polyaniline on a titanium alloy (Ti-6Al-4V) rod. 16 The second approach is based on the swelling of H + -sensitive hydrogels which requires an X-ray source, thus a laboratory set-up instrument.…”