Objective: To assess the feasibility of implementing a simple point-of-care lung ultrasound (POC-LUS) evaluation and reporting protocol in a neonatal intensive care unit (NICU) and its effect on patient management.Study design: Retrospective observational study of POC-LUS examinations performed in a level III NICU. Each examination was performed according to a standardized protocol. An independent radiologistassessed chest X-ray (CXR) was used to compare the POC-LUS diagnosis. The impact on patient management was also evaluated.Result: A total of 206 POC-LUS studies in 158 neonates were reviewed. There was signi cant agreement between POC-LUS and CXR diagnoses (84,95%, 95% CI 80,07-89,83%).POC-LUS affected patient management in 87.8% of the cases (95% CI 83,33-92,28%).Conclusion: Implementation of a simpli ed, sign-based protocol for POC-LUS in the NICU is feasible. POC-LUS is not inferior to CXR studies and supports patient management as an imaging modality.