Point‐of‐care testing for influenza in a university emergency department: A prospective study

Perlitz, Benjamin; Slagman, Anna; Hitzek, Jennifer; Riedlinger, Dorothee; Möckel, Martin

doi:10.1111/irv.12857

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…A rapid and easy diagnostic method is mandatory for proper management and improves outcomes. The point-of-care (POC) antigen test for respiratory syncytial virus, in uenza A, B, and human metapneumovirus is widely available and has been used for primary clinical care (4)(5)(6). However, there are many other important respiratory viruses to care for clinically.…”

Section: Introductionmentioning

confidence: 99%

Investigation of respiratory viruses by multiplex PCR method in the community suggested reciprocal virus transmission between children and adults

Nagasawa

2022

Preprint

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The observational study of respiratory virus infection for children has already been reported, but there are few reports that examined both children and adults simultaneously in the community. We performed a multiplex PCR (polymerase-chain reaction) assay of respiratory viruses by using FilmArray respiratory panel version 2.1 for 248 children (under 15 years old) and 5,354 adults (15 years old or older) who were admitted or visited our hospital with respiratory symptoms and/or fever from December 2020 to November 2021. During this period, a seasonal outbreak of respiratory syncytial virus (RSV) and parainfluenza virus 3 (PI3) was found as well as a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In adults, viruses were detected in 6.8% (364/5,354), and SARS-CoV-2 accounted for 228 cases. Only two cases presented multiple viruses. In children, viruses were detected in 64.9% (161/248), while 75.4% (135/179) were under 5 years old. Multiple viruses were detected in 26 cases, all of which were under 5 years old. SARS-CoV-2 was positive in six children. RSV prevailed both in children and adults simultaneously, while the PI3 outbreak was found first in children, followed by adults three weeks later. Rhinovirus/enterovirus (RV/EV) was detected throughout the year with some fluctuation and was mostly found in children under 5 years old and in adults aged between 20s and 30s, which suggested reciprocal virus transmission between the children and the parents.

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Section: Introductionmentioning

confidence: 99%

Investigation of respiratory viruses by multiplex PCR method in the community suggested reciprocal virus transmission between children and adults

Nagasawa

2022

Preprint

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“…Neither Hausfater et al [ 30 ] nor Asha et al [ 31 ] were able to achieve a significant reduction in ED LOS through POC testing. In other studies, specifically related to infectious respiratory diseases such as influenza, a reduction in ED LOS was again possible [ 7 , 32 ].…”

Section: Discussionmentioning

confidence: 97%

“…Therefore, reducing inpatient LOS is considered of major importance. Early detection of other viral infections, such as influenza, via point-of-care (POC) testing has proven to shorten the time until specific treatment was started [ 7 ] and to promote timely transfer to specialised wards in order to reduce inpatient LOS [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Different SARS-CoV-2 Testing Strategies in the Emergency Department on Length of Stay and Clinical Outcomes: A Randomised Controlled Trial

Boldt,

Bolanaki,

Holert

et al. 2024

Canadian Journal of Infectious Diseases and Medical Microbiolog

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The turn-around-time (TAT) of diagnostic and screening measures such as testing for SARS-CoV-2 can affect a patient’s length of stay (LOS) in the hospital as well as the emergency department (ED). This, in turn, can affect clinical outcomes. Therefore, a reliable and time-efficient SARS-CoV-2 testing strategy is necessary, especially in the ED. In this randomised controlled trial, n = 598 ED patients presenting to one of three university hospital EDs in Berlin, Germany, and needing hospitalisation were randomly assigned to two intervention groups and one control group. Accordingly, different SARS-CoV-2 testing strategies were implemented: rapid antigen and point-of-care (POC) reverse transcription polymerase chain reaction (rtPCR) testing with the Roche cobas® Liat® (LIAT) (group one n = 198), POC rtPCR testing with the LIAT (group two n = 197), and central laboratory rtPCR testing (group three, control group n = 203). The median LOS in the hospital as an inpatient across the groups was 7 days. Patients’ LOS in the ED of more than seven hours did not differ significantly, and furthermore, no significant differences were observed regarding clinical outcomes such as intensive care unit stay or death. The rapid and POC test strategies had a significantly (p<0.01) shorter median TAT (group one 00:48 h, group two 00:21 h) than the regular central laboratory rtPCR test (group three 06:26 h). However, fast SARS-CoV-2 testing strategies did not reduce ED or inpatient LOS significantly in less urgent ED admissions. Testing strategies should be adjusted to the current circumstances including crowding, SARS-CoV-2 incidences, and patient cohort. This trial is registered with DRKS00023117.

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“…POC testing is standard in the ED for clinical chemistry parameters like lactate, electrolytes or cardiac troponin. For molecular diagnostics there have been first attempts with influenza POC testing ( Perlitz et al, 2021 ). Due to the high importance of the test results, which touch regulatory aspects like hygiene rules and due the fast disposition and transfers (i.e.…”

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 screening in patients in need of urgent inpatient treatment in the Emergency Department (ED) by digitally integrated point-of-care PCR: a clinical cohort study

Möckel

Bolanaki

Hofmann

et al. 2022

Diagnostic Microbiology and Infectious Disease

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Patients in need of urgent inpatient treatment were recruited prospectively. A rapid point of care PCR test (POC-PCR; Liat®) for SARS-CoV2 was conducted in the ED and a second PCR-test from the same swab was ordered in the central laboratory (CL-PCR). POC-PCR analyzers were digitally integrated in the laboratory information system. Overall, 160 ED patients were included. A valid POC-PCR-test result was available in 96.3% (n=154) of patients. N=16 patients tested positive for SARS-CoV-2 (10.0%). The POC PCR test results were available within 102 minutes (median, IQR: 56-211), which was significantly earlier compared to the CL PCR (811 minutes; IQR: 533-1289, p < 0.001). The diagnostic accuracy of the POC- PCR test was 100%. The implementation and digital LIS integration was successfully done. Staff satisfaction with the POC process was high. The POC-PCR testing in the emergency department is feasible and shows a very high diagnostic performance. Trial registration: DRKS00019207

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Point‐of‐care testing for influenza in a university emergency department: A prospective study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 17 publications

Investigation of respiratory viruses by multiplex PCR method in the community suggested reciprocal virus transmission between children and adults

Investigation of respiratory viruses by multiplex PCR method in the community suggested reciprocal virus transmission between children and adults

Effects of Different SARS-CoV-2 Testing Strategies in the Emergency Department on Length of Stay and Clinical Outcomes: A Randomised Controlled Trial

SARS-CoV-2 screening in patients in need of urgent inpatient treatment in the Emergency Department (ED) by digitally integrated point-of-care PCR: a clinical cohort study

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