Point-of-Care Testing in Acute Hemorrhagic and Thrombotic States

Welcome to Seminars in Thrombosis & Hemostasis 2021—New (2019) Impact Factor and Most Highly Cited Papers

“…37 Several issues of the journal are also worthy to be highlighted as most of them contributed to the 2019 impact factor. The seven most highly contributing issues, [40][41][42][43][44][45][46] both in terms of total and average impact factor contributions, were:…”

Point-of-Care Assessment of Hemostasis with a Love-Mode Surface Acoustic Wave Sensor

“…Ideally, it is believed that these tests can be done at the bedside with reduced volume of blood, and there is no requirement for blood sample preprocessing (centrifugation and buffering) and skilled laboratory personnel . Some of these even claim to deliver a better overall picture of the coagulation system, including platelet function, fibrin clot formation, and fibrinolysis . In the past decade, different kinds of methods for POC blood coagulation tests have been reported, such as optics, laser speckle rheology, , micropost arrays, , microfluidic dielectric sensor, rational microfluidic device, paper microfluidics, − electrical impedance sensing, effervescent pump-based device, etc.…”

“…19 Some of these even claim to deliver a better overall picture of the coagulation system, including platelet function, fibrin clot formation, and fibrinolysis. 20 In the past decade, different kinds of methods for POC blood coagulation tests have been reported, such as optics, 21 laser speckle rheology, 22,23 micropost arrays, 24,25 microfluidic dielectric sensor, 26 rational microfluidic device, 27 paper microfluidics, 28−30 electrical impedance sensing, 31 effervescent pumpbased device, 32 etc. They all have their pros and cons, and none of the methods currently available measures all of the hemostasis processes involving adhesion of platelets to the damaged endothelium, formation of a platelet plug (aggregation), formation of a fibrin network to stabilize the plug, clot retraction, and finally fibrinolysis.…”