Point-of-Care Testing in Hospitals and Primary Care

Junker, Ralf; Schlebusch, H.; Luppa, Peter B.

doi:10.3238/arztebl.2010.0561

Cited by 64 publications

(64 citation statements)

References 20 publications

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“…The potential applications for fully integrated multiplexed POC molecular analysis solutions are enormous, including doctor's office testing, patient self-care, remote access to medical care, and national security (1,27 ). Because of its inherent ruggedness, speed, analytical power, economy, and diversity of applications, this method has the potential to meet the exacting standards required for POC diagnostics applications.…”

Section: Discussionmentioning

confidence: 99%

Whole Blood Immunoassay Based on Centrifugal Bead Sedimentation

Schaff

Sommer

2011

Clinical Chemistry

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BACKGROUND:Centrifugal "lab on a disk" microfluidics is a promising avenue for developing portable, lowcost, automated immunoassays. However, the necessity of incorporating multiple wash steps results in complicated designs that increase the time and sample/reagent volumes needed to run assays and raises the probability of errors. We present proof of principle for a disk-based microfluidic immunoassay technique that processes blood samples without conventional wash steps.

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Section: Discussionmentioning

confidence: 99%

Whole Blood Immunoassay Based on Centrifugal Bead Sedimentation

Schaff

Sommer

2011

Clinical Chemistry

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“…This is of particular relevance in a hospital setting, where medically urgent cases may require fast and efficient treatment. 3 To ensure patient safety, specific quality control guidelines developed in Europe define maximum permissible deviations from the target values for control measurements in point-of-care settings:…”

Section: Technology Reportmentioning

confidence: 99%

Performance of a Blood Glucose Monitoring System in a Point-of-Care Setting

Ottiger

Gygli

Huber

et al. 2016

J Diabetes Sci Technol

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This study assesses and demonstrates that CONTOUR® XT-BGMS (CXT-BGMS) complies with the requirements of the German (RiliBÄK) and Swiss (QUALAB) quality control guidelines for point-of-care testing (POCT) and fulfills the ISO15197:2013 accuracy limits criteria under the routine conditions of a hospital point-of care setting. This single-center study was conducted in Switzerland using 105 venous blood samples from hospitalized patients. Each sample was tested in comparison to the hexokinase reference method. Compliance with POCT guidelines was assessed by daily BGMS measurements using control solutions. Accuracy of CXT-BGMS according to ISO limits was 98.41%. All control measurements were within the limits defined by RiliBÄK (within ± 11% of target values and root mean square error [RMSE] within RMSE limits), and QUALAB (within ± 10% of target values).

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“…8b). The submicrometer-sized UCP crystals were physically bead-milled from a bulk La 2 , Er 3+ material. Regardless of the less optimal UCPs, a similar detection limit (below 0.5 nM) was achieved.…”

Section: Upconversion Resonance Energy Transfermentioning

confidence: 99%

“…In certain applications, also the stability issues (i.e., photobleaching) may disturb the use of organic fluorophores. The recent trend in assay development has been toward point-of-care testing (POCT) [2,3], which will inevitably reshape the conventions of the sample analysis as an option for the high-capacity centralized laboratory testing. The label technology used for analyte quantification in POCT system plays an important role in order to allow sensitive (i.e., low detection limit), simple (i.e., small-sized reader), and low-cost (i.e., inexpensive materials and instrumentation) detection.…”

Section: Introductionmentioning

confidence: 99%

Upconverting Phosphor Labels for Bioanalytical Assays

Riuttamäki

Soukka

2013

Advances in Chemical Bioanalysis

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Upconverting phosphors (UCPs) are photoluminescent inorganic crystals capable of photon upconversion upon absorption of two or more sequential photons. UCPs produce bright, structured emission at wavelengths shorter than the excitation radiation rendering them highly advanced labels for bioanalytical assays. The exceptional anti-Stokes emission allows total elimination of autofluorescence originating mainly from biomolecules and other sample components. UCPs are excited with near-infrared radiation which provides several advantages over ultraviolet excitation-including optimal penetration of biological material. This chapter summarizes the bioanalytical in vitro applications of UCPs and discusses the advantages and challenges of the emerging label technology. In addition, synthesis of the UCP labels and some of the instruments used for UCP detection are shortly reviewed. Bioimaging and therapeutic applications based on UCPs are outside of the scope of this chapter.

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Point-of-Care Testing in Hospitals and Primary Care

Abstract: POCT for certain applications is a useful complement to conventional laboratory testing. The future utilization of POCT will depend not only on technical advances, but also on developments in costs and reimbursement.

Cited by 64 publications

References 20 publications

Whole Blood Immunoassay Based on Centrifugal Bead Sedimentation

Whole Blood Immunoassay Based on Centrifugal Bead Sedimentation

Performance of a Blood Glucose Monitoring System in a Point-of-Care Setting

Upconverting Phosphor Labels for Bioanalytical Assays

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