Point-of-care testing of cardiac markers: results from an experience in an Emergency Department

Altinier, Sara; Zaninotto, Martina; Mion, Monica; Carraro, Paolo; Rocco, Stefano; Tosato, Franco; Plebani, Mario

doi:10.1016/s0009-8981(01)00562-9

Cited by 27 publications

(11 citation statements)

References 15 publications

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“…Numerous trials have demonstrated compelling decreases in turnaround time, and it is often assumed this translates to improvements in disposition time, ED LOS, patient satisfaction, cost, time to treatment, and clinical outcome 14,15,17–29 . For example, in ACS management, ED point‐of‐care testing has been suggested to not only reduce time to test results, 14,23,30,31 but also to offer the advantages of no interruption in the clinical decision making process and reductions in LOS 18 .…”

Section: Discussionmentioning

confidence: 99%

Decreasing Lab Turnaround Time Improves Emergency Department Throughput and Decreases Emergency Medical Services Diversion: A Simulation Model

Storrow

Zhou

Gaddis

et al. 2008

Academic Emergency Medicine

114

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Section: Discussionmentioning

confidence: 99%

Decreasing Lab Turnaround Time Improves Emergency Department Throughput and Decreases Emergency Medical Services Diversion: A Simulation Model

Storrow

Zhou

Gaddis

et al. 2008

Academic Emergency Medicine

114

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“…, Altiner et al . ) and to deliver follow‐up treatment; these activities have been found to shorten hospital stays and minimise complications (Price ). On the other hand, it has also been reported that POCT does not reduce the period of hospitalisation (Parvin et al .…”

Section: Introductionmentioning

confidence: 99%

Training of nurses in point‐of‐care testing: a systematic review of the literature

Liikanen

Lehto

2013

Journal of Clinical Nursing

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“…To expedite treatment and improve outcomes, tests with shorter turn-around times and point of care testing (POCT) devices are needed. The rationale for using POCT of cardiac proteins has been justified in large-scale studies [1, 7–9]. Unfortunately, commercial POCT devices commonly do not produce the same results as the central laboratory analyzers, which is a requirement for consistent clinical interpretation of the measured values [4, 10].…”

Section: Introductionmentioning

confidence: 99%

Surface plasmon resonance aided electrochemical immunosensor for CK-MB determination in undiluted serum samples

et al. 2010

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This article presents a simple chronoamperometric immunosensor for the quantitative assessment of creatine kinase MB (CK-MB) in 50 µL undiluted serum samples. The immunosensor consists of gold working and counter electrodes patterned onto a glass chip by thin-film photolithography and an external Ag|AgCl reference electrode. The detection limit (DL) of the chronoamperometric method is 13 ng mL −1 (DL = 2×RMSD/S, where RMSD is the residual mean standard deviation of the measured points around a calibration curve with a slope of S). In spiked serum samples, the response was linear up to 300 ng mL −1 of CK-MB. A surface plasmon resonance (SPR) system with simultaneous electrochemical detection (EC-SPR) aided the development of the sandwich immunoassay. Real-time monitoring of the SPR signal was used to optimize the capture antibody immobilization, CK-MB and detection antibody binding, as well as to minimize the nonspecific adsorption of serum proteins to the sensor surface. The detection antibody has been labeled with alkaline phosphatase (ALP) enzyme for sensitive electrochemical detection. ALP catalyzes the hydrolysis of ascorbic acid phosphate and generates ascorbic acid, which is measured chronoamperometrically. The electrochemical immunoassay for CK-MB was less sensitive to nonspecific adsorption related interferences, had a better detection limit, and required a lower volume of sample than the SPR method.

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Point-of-care testing of cardiac markers: results from an experience in an Emergency Department

Cited by 27 publications

References 15 publications

Decreasing Lab Turnaround Time Improves Emergency Department Throughput and Decreases Emergency Medical Services Diversion: A Simulation Model

Decreasing Lab Turnaround Time Improves Emergency Department Throughput and Decreases Emergency Medical Services Diversion: A Simulation Model

Training of nurses in point‐of‐care testing: a systematic review of the literature

Surface plasmon resonance aided electrochemical immunosensor for CK-MB determination in undiluted serum samples

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