Point-of-Use Sweat Biosensor to Track the Endocrine–Inflammation Relationship for Chronic Disease Monitoring

Upasham, Sayali; Bhide, Ashlesha; Lin, Kai‐Chun; Prasad, Shalini

doi:10.2144/fsoa-2020-0097

Cited by 14 publications

(10 citation statements)

References 35 publications

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“…This reaction ensures the chemisorptive anchoring of the antibody on the sensing surface. From the FTIR spectrum, antibody immobilization is evident from the peaks between the 1600–1655 cm –1 range for the amide I bond and the 1500–1580 cm –1 for the amide II bond. , These peaks are contributed by the secondary structure of the protein molecule, that is, antibody. Also, the appearance of the CNC stretch of the aliphatic amines in the range between 1000 and 1200 cm –1 highlights the successful conjugation between the thiol linker and the antibody.…”

Section: Resultsmentioning

confidence: 99%

Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection

Upasham

Prasad

2021

ACS Omega

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SLOCK (sensor for circadian clock) is an electrochemical sweatbased biosensing platform designed for the diagnosis and management of circadian abnormalities. Previously, the SLOCK platform was designed to detect adrenal steroids, cortisol, and DHEA for tracking the circadian rhythm. This work aims at tuning this SLOCK platform toward the detection of the cytokine, interleukin-31, for building a noninvasive, chronic disease diagnostics and management platform. This research provides a detailed characterization of the sensing surface and immunochemistry. The results show that SLOCK has good sensitivity to IL-31 concentrations in synthetic and human sweat. The limit of detection is 50 and 100 pg/mL for synthetic and human sweat, respectively. The dynamic range of the system is 50−1000 pg/mL, which encompasses the physiological ranges of 150−620 pg/mL. This is the first demonstration of sweat-based, label-free, electrochemical detection of IL-31. In addition to this, the data show good correlation (R 2 > 0.95) for the signal sensitivity to biomarker concentration. Finally, cross-reactivity studies highlight the specificity of SLOCK even in the presence of highly cross-reactive species. Thus, this novel SLOCK biosensor can be successfully used to track IL-31 in a sensitive and noninvasive manner and could be used to identify chronic pathophysiologies present in the body.

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Section: Resultsmentioning

confidence: 99%

Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection

Upasham

Prasad

2021

ACS Omega

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“…Smart Skin describes specific sensors worn directly on the skin, which can measure a wide range of parameters. From physical quantities (e.g., pressure, temperature, or humidity) to chemical parameters such as biomarkers in human fluids there are no limits [132,133]. Additionally, for biomarkers and factors associated with QoL impairment in PSO and AD this technique could be useful in future.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Psoriasis and Atopic Dermatitis on Quality of Life: A Literature Research on Biomarkers

Balato

Zink

Babino

et al. 2022

Life

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Psoriasis (PSO) and Atopic dermatitis (AD) are common inflammatory skin diseases that affect people of all ages globally. They negatively impact the quality of life (QoL) of patients in health-related aspects such as physical, psychological and mental functioning. Here, we conducted a review of studies relating to candidate biomarkers and indicators associated with QoL impairment in PSO and AD. Data research was performed using PUBMED and SCOPUS databases from inception to September 2022. Most of the included studies reported genomic or proteomic biomarkers associated with disease activity and QoL outcomes. Sociodemographic, clinical and therapeutic factors have also been implicated in deterioration of life quality in these patients. The inclusion of clinical characteristics, QoL impairment and co-diagnosis should be considered in drug development programs, since processing biomarkers based on an increased number of features in addition to drug class and disease will intensify the value of the biomarker itself, thereby maximizing the future clinical utility as a stratification tool.

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“…Although the response depicted is a cumulative change, the spike and fall can be easily seen by performing slope extraction, as shown in the paper. Similarly, another paper by our group 43 investigates the sensitivity of a multibiomarker detection platform over the periods of 1 and 5.5 h continuously. Over the period of 1 h, rise and fall in cortisol levels is investigated with concentrations going from 1 to 100 ng/mL and back down to 10 ng/mL.…”

Section: Wearable Circadian Diagnosticsmentioning

confidence: 99%

Sweating Out the Circadian Rhythm: A Technical Review

et al. 2021

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Circadian dysfunction or dysregulation is associated with many chronic morbidities. Current state-of-art technologies do not provide an accurate estimation of the extent of disease affliction. Recent advances call for using wearables for improving management and diagnosis of circadian related disorders. Sweat contains an abundance of relevant biomarkers like cortisol, DHEA, and so forth, which could be leveraged toward tracking the user's chronobiology. In this article, we provide a review of the key developments in the field of wearable sensors for circadian technologies. We highlight the value of using sweat along with portable electronics toward developing state-of-the-art platforms for efficient diagnosis and management of chronic conditions. Finally, we discuss challenges and opportunities for using wearable sweat sensors for circadian diagnosis and disease management.

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Point-of-Use Sweat Biosensor to Track the Endocrine–Inflammation Relationship for Chronic Disease Monitoring

Cited by 14 publications

References 35 publications

Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection

Tuning SLOCK toward Chronic Disease Diagnostics and Management: Label-free Sweat Interleukin-31 Detection

The Impact of Psoriasis and Atopic Dermatitis on Quality of Life: A Literature Research on Biomarkers

Sweating Out the Circadian Rhythm: A Technical Review

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