Point prevalence survey of antibiotic use in French hospitals in 2009

Robert, Jérôme; Péan, Y.; Varon, Emmanuelle; Bru, J.P.; Bédos, Jean‐Pierre; Bertrand, Xavier; Lepape, Alain; Stahl, J.-P.; Gauzit, R.

doi:10.1093/jac/dkr571

Cited by 62 publications

(57 citation statements)

References 21 publications

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“…This Shows a high use of antibiotics after emergence of proven or assumed bacterial infections. These results confirmed the conclusion of previous studies (Vlahović-Palcevski et al, 2007;N'diaye, 2003), but they are higher compared to the results obtained by other studies (Zarb et al, 2011;Robert et al, 2012;Toure et al, 1997). The high use of antibiotics might increase the risk of bacterial resistance to some antibiotics; however, it is important to note that the difference between the prevalence found in this study and in previous studies does not necessarily indicate that there is inappropriate use of antibiotics where prevalence is high.…”

Section: Discussionsupporting

confidence: 91%

“…The ways of prescriptions encountered in the two health zones of Butembo city are not identical to those found in hospitals in France (Robert et al, 2012). Indeed, in France, 3rd generation cephalosporins and betalactam associated with beta-lactamase inhibitors accounted with 44%, while in the present study is ampicillin, an aminopenicillin is prescribed by 35%.…”

Section: Discussioncontrasting

confidence: 68%

See 1 more Smart Citation

Point prevalence study of antibiotic use in hospitals in Butembo

Wambale¹,

Iyamba²,

Mathe³

et al. 2016

Int. J. Med. Med. Sci.

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Inappropriate use of antibiotics is known as an important risk factor in the development of antibiotic resistance which increases the morbidity and mortality. We aimed to determine the prevalence and characteristics of antibiotic use in hospitals. A prevalence survey was conducted in 11 hospitals from 1 st to 31 th October 2014. In this study, from 700 patients investigated in this study, 476 received at least one antibiotic for their treatment; the prevalence of the antibiotic use was 68%. Most of patients were female (59.1%) and aged between 16 and 30 years. The most attended service was internal medicine (34%). 19 diseases were identified, malaria exhibited the highest prevalence (21.6%) followed by surgical site infections (10.7%), urogenital infections (8.6%), and infectious symptoms (8.4%) and bronchitis (8%). The 476 treated patients received a total of 667 antibiotic drugs (1.4 antibiotics per patient). The most prescribed antibiotic was ampicillin (35%) followed by gentamicin (13.6%), amoxicillin (13.5%), ceftriaxone (11%) and metronidazole (10.3%). The prevalence of combined therapy was 34.9% among patients who received more than one antibiotic. The most common route of administration was the intravenous (68.2%) and the most pharmaceutical form used was the powder for injection (51.1%). The prevalence of antibiotic use in Butembo hospital environment was very high which could be a risk factor for the development of resistance in case of inappropriate use of antibiotics.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 68%

Point prevalence study of antibiotic use in hospitals in Butembo

Wambale¹,

Iyamba²,

Mathe³

et al. 2016

Int. J. Med. Med. Sci.

View full text Add to dashboard Cite

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“…Although compliance with appropriate timing and spectrum of AP have improved as a result of quality improvement initiatives, there remain significant deficiencies in compliance with other aspects of AP such as duration of post-operative antibiotics [3][4][5]. Given that approximately 15% of all antibiotic agents in hospitals are prescribed for surgical prophylaxis [6,7], peri-operative antibiotic prescribing patterns can be a major driver of some emerging infections (such as C. difficile) [8,9] and selection of antibiotic resistance, thus increasing healthcare costs.…”

Section: Antibiotic Prophylaxismentioning

confidence: 99%

Antimicrobial Stewardship: A Call to Action for Surgeons

Sartelli

Duane

Catena

et al. 2016

Surgical Infections

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Despite current antimicrobial stewardship programs (ASPs) being advocated by infectious disease specialists and discussed by national and international policy makers, ASPs coverage remains limited to only certain hospitals as well as specific service lines within hospitals. The ASPs incorporate a variety of strategies to optimize antimicrobial agent use in the hospital, yet the exact set of interventions essential to ASP success remains unknown. Promotion of ASPs across clinical practice is crucial to their success to ensure standardization of antimicrobial agent use within an institution. To effectively accomplish this standardization, providers who actively engage in antimicrobial agent prescribing should participate in the establishment and support of these programs. Hence, surgeons need to play a major role in these collaborations. Surgeons must be aware that judicious antibiotic utilization is an integral part of any stewardship program and necessary to maximize clinical cure and minimize emergence of antimicrobial resistance. The battle against antibiotic resistance should be fought by all healthcare professionals. If surgeons around the world participate in this global fight and demonstrate awareness of the major problem of antimicrobial resistance, they will be pivotal leaders. If surgeons fail to actively engage and use antibiotics judiciously, they will find themselves deprived of the autonomy to treat their patients.Keywords: antibiotic prophylaxis; intra-abdominal infection; necrotizing soft tissue infection; surgical site infection; trauma A lthough most surgeons are aware of the problem of antimicrobial resistance, most underestimate this problem in their own hospital. Surgeons should always optimize antimicrobial management to maximize clinical outcome and minimize emergence of antimicrobial resistance. The necessity of formalized systematic approaches to the optimization of antibiotic therapy in the setting of surgical units worldwide, both for elective and emergency admissions, has become increasingly urgent.In 2013, a Cochrane review was published to estimate the effectiveness of professional interventions in antibiotic stewardship for hospital inpatients and to evaluate the impact of these interventions on reducing the incidence of antimicrobial resistance or Clostridium difficile infection [1]. The results showed that interventions to reduce excessive antibiotic prescribing to hospital inpatients were able to reduce antimicrobial resistance and hospitalacquired infections (HAIs), improving clinical outcome. The meta-analysis supported the use of restrictive interventions when the need is urgent, but suggested that persuasive and restrictive interventions are equally effective after six months.

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“…Studies have shown that approximately 15% of all antibiotics in hospitals are used for SAP [6,7]. Furthermore, studies from different countries have found that SAP was used excessively and inappropriately [8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%