Points to Consider in Health Assessment of Adult Patients with Primary Antibody Deficiencies

Napiórkowska-Baran, Katarzyna; Ziętkiewicz, Marcin; Więsik-Szewczyk, Ewa; Matyja-Bednarczyk, Aleksandra; Tykwińska, Marta; Alska, Ewa; Rosada, Tomasz; Szynkiewicz, Ewa; Lubański, Jakub; Schmidt, Oskar; Szymczak, Bartłomiej; Koperska, Kinga; Bartuzi, Zbigniew

doi:10.3390/jcm12186018

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Research conducted by the author of this article on a group of patients with primary immunodeficiency revealed reduced hemoglobin concentration in 32%, total protein in 19%, albumin in 17%, vitamin D3 in 52% (despite recommended supplementation), vitamin B12 in 6.5%, folic acid in 34%, and ferritin in 26% of patients. It is important to note that the study was performed on a group of patients who regularly attend medical appointments and undergo periodical examinations [269]. Diabetes is a secondary immune deficiency, and patients who have been diagnosed with it should also be carefully examined for nutritional deficiencies.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Napiórkowska-Baran,

Treichel,

Czarnowska

et al. 2024

IJMS

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An organism’s ability to function properly depends not solely on its diet but also on the intake of nutrients and non-nutritive bioactive compounds that exert immunomodulatory effects. This principle applies both to healthy individuals and, in particular, to those with concomitant chronic conditions, such as type 2 diabetes. However, the current food industry and the widespread use of highly processed foods often lead to nutritional deficiencies. Numerous studies have confirmed the occurrence of immune system dysfunction in patients with type 2 diabetes. This article elucidates the impact of specific nutrients on the immune system function, which maintains homeostasis of the organism, with a particular emphasis on type 2 diabetes. The role of macronutrients, micronutrients, vitamins, and selected substances, such as omega-3 fatty acids, coenzyme Q10, and alpha-lipoic acid, was taken into consideration, which outlined the minimum range of tests that ought to be performed on patients in order to either directly or indirectly determine the severity of malnutrition in this group of patients.

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Section: Discussionmentioning

confidence: 99%

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Napiórkowska-Baran,

Treichel,

Czarnowska

et al. 2024

IJMS

Self Cite

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Fecal microbiota transplantation in a patient with chronic diarrhea and primary and secondary immunodeficiency (common variable immunodeficiency and splenectomy)

Napiórkowska-Baran,

Biliński,

Pujanek

et al. 2024

Front. Cell. Infect. Microbiol.

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The gut microbiota serves a crucial role in the development of host immunity. Immunocompromised patients are particularly vulnerable to dysbiosis not only by virtue of a defect in the immune system but also due to increased susceptibility to infection and multiple courses of antibiotic therapy. Fecal microbiota transplantation is by far the most effective option for restoring gastrointestinal homeostasis. However, it is contraindicated in patients with significant primary and secondary immunodeficiencies. This article presents the case of a 59-year-old patient with common variable immunodeficiency, after splenectomy at age 39 for primary immune thrombocytopenia, who manifested diarrhea of up to 10 stools per day accompanied by secondary malnutrition and cachexia. The patient was admitted to the hospital on multiple occasions due to this condition, with stool PCR tests confirming a HHV-5 (Cytomegalovirus, CMV) infection. Following the administration of valganciclovir, the patient’s complaints diminished, although, upon cessation of the drug, the symptoms recurred. In addition, the patient had an intestinal infection with C. difficile etiology. Given that the patient’s therapeutic options had been exhausted, after obtaining informed consent from the patient and approval from the bioethics committee to conduct a medical experiment, treatment of diarrhea was undertaken by fecal microbiota transplantation with the certified preparation Mbiotix HBI from the Human Biome Institute. The patient underwent two transplants, with a one-week interval between them. The initial procedure was performed using the endoscopic method, while the subsequent was conducted using the capsule method. Following the administration of the applied treatment, the patient’s symptoms were successfully alleviated, and no adverse effects were observed. A microbiological analysis of the intestinal microbiota was conducted prior to and following transplantation via next-generation sequencing (NGS). No recurrence of symptoms was observed during the two-year follow-up period. To the best of our knowledge, this is the first fecal microbiota transplantation in an adult patient with primary and secondary immunodeficiency.

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Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1—Primary Immunodeficiencies

Napiórkowska-Baran,

Doligalska,

Drozd

et al. 2024

Healthcare

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Background: Cardiovascular diseases are some of the most prevalent chronic diseases that generate not only high social but also economic costs. It is becoming increasingly crucial to take into account inborn errors of immunity (IEIs, formerly known as primary immunodeficiencies (PIDs)) and secondary immunodeficiencies (SIDs) in the diagnostic and therapeutic management of cardiac patients. The number of diseases classified as IEIs is on the rise, with a current total of 485. It is essential to pay attention not only to already confirmed conditions but also to symptoms suggestive of immunodeficiencies. Objectives: The aim of this article is to present IEIs with cardiovascular symptoms that may cause or exacerbate cardiovascular disease, as well as diagnostic and therapeutic procedures. Results: It is becoming increasingly evident that immunodeficiencies can be responsible for certain cardiovascular conditions, their hastened progression, and difficulties in their control. Conclusions: Early detection of deficiencies improves not only the quality and longevity of patients, but also allows for better control of cardiovascular diseases and even prevention of their occurrence.

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Points to Consider in Health Assessment of Adult Patients with Primary Antibody Deficiencies

Cited by 3 publications

References 26 publications

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Immunomodulation through Nutrition Should Be a Key Trend in Type 2 Diabetes Treatment

Fecal microbiota transplantation in a patient with chronic diarrhea and primary and secondary immunodeficiency (common variable immunodeficiency and splenectomy)

Management of a Patient with Cardiovascular Disease Should Include Assessment of Primary and Secondary Immunodeficiencies: Part 1—Primary Immunodeficiencies

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