Several results concerning multipliers of symmetric Banach function spaces are presented firstly. Then the results on multipliers of Calderón-Lozanovskiȋ spaces are proved. We investigate assumptions on a Banach ideal space E and three Young functions ϕ1 , ϕ2 and ϕ, generating the corresponding Calderón-Lozanovskiȋ spaces Eϕ 1 , Eϕ 2 , Eϕ so that the space of multipliers M (Eϕ 1 , Eϕ ) of all measurable x such that x y ∈ Eϕ for any y ∈ Eϕ 1 can be identified with Eϕ 2 . Sufficient conditions generalize earlier results by Ando, O'Neil, Zabreȋko-Rutickiȋ, Maligranda-Persson and Maligranda-Nakai. There are also necessary conditions on functions for the embedding M (Eϕ 1 , Eϕ ) ⊂ Eϕ 2 to be true, which already in the case whengive a solution of a problem raised in the book [26]. Some properties of a generalized complementary operation on Young functions, defined by Ando, are investigated in order to show how to construct the function ϕ2 such that M (Eϕ 1 , Eϕ ) = Eϕ 2 . There are also several examples of independent interest.