Poisoning with Oxybutynin

Abstract

<jats:p> A case of poisoning with 100 mg of oxybutynin in a 34-year-old female is reported. The main features were anticholinergic effects, including stupor, followed by disorientation and agitation on awakening, dilated pupils, dry skin and retention of urine. She had a sinus tachycardia which resolved 3 h after admission, and in addition ventricular ectopics and bigeminy which continued for a further 30 h. She recovered fully on symptomatic treatment alone. </jats:p>

Hallucinations after hypospadias repair

“…The skin is dry and flushed because perspiration is inhibited. Nausea, vomiting, arrhythmias, respiratory failure, and hypotension may also occur [3]. Neuropsychiatric effects have been reported even when used at the recommended dose [4].…”

The Q-T interval and antimuscarinic drugs

“…However, the antimuscarinic effects of the tertiary and quaternary amines used for pharmacologic treatment of the OAB provide the potential for antimuscarinic activity, which could have potential negative cardiac effects. For example, oxybutynin overdosage (100 mg) has been associated with ventricular bigeminy and ventricular ectopy [10].…”

The q-t interval and antimuscarinic drugs

“…For example, oxybutynin overdosage (100 mg) has been associated with ventricular bigeminy and ventricular ectopy [10]. Limited data have suggested no effect on the Q-T interval with agents such as oxybutynin or tolterodine.…”