Pola Pneumonia Nosokomial di Unit Perawatan Intensif Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Periode Januari–Desember 2017

Salukanan, Ronald Tikuali; Zulfariansyah, Ardi; Sitanggang, Ruli Herman

doi:10.15851/jap.v6n2.1337

Cited by 2 publications

(4 citation statements)

References 17 publications

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“…The most commonly isolated Gram-negative bacteria in our study ( A. baumannii , K. pneumoniae , and P. aeruginosa ) are in line with previous systematic review [ 31 ]. These organisms have been identified as the main causative bacteria of infections among ventilator users in different ICUs in Indonesia [ 6 , 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pneumonia is the most common nosocomial infection among hospitalized patients, and those treated in the intensive care unit (ICU) on ventilators are at 2-12 times higher risk of developing nosocomial pneumonia [3][4][5]. Hospital-acquired pneumonia has been reported to account for more than half of the total infection cases in ICU [3], as well as the leading cause of mortality in this setting [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Distribution and antibacterial susceptibility pattern of isolated bacteria from endotracheal aspirates among ventilator-assisted pneumonia patients in Indonesia

Andayani

Mahdani

Nisyra

et al. 2023

Narra J

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An accurate and timely identification of causative microorganisms as well as determination of their antibiotic susceptibility patterns will help in the selection of proper antibiotics and prevention of their misuse in pneumonia patients. The aim of this study was to determine the distribution and antibiotic susceptibility pattern of bacteria isolated from endotracheal aspirates of ventilator-assisted pneumonia patients in Indonesia. A retrospective cross-sectional study was conducted at Dr. Zainoel Abidin Hospital, a provincial reference hospital in Banda Aceh, Indonesia, from January to December 2021. Ventilator-assisted pneumonia patients aged ≥17 years treated in the hospital were considered eligible. Antibiotic susceptibility was valuated using Kirby-Bauer disc-diffusion followed with VITEK 2 Compact. We included 57 patients of which 73.7% males and 26.3% aged 56–65 years (represent the majority group of the patients). Each patient reported at least one comorbidity and the average duration of receiving mechanical ventilation was 8.68 days, and more than half (59.7%) of the patients had a poor clinical outcome (died). A total 57 bacteria isolates (consisting nine species) were recovered; 68.5% Gram-negative and 31.5% Gram-positive bacteria. Among 57 patients, Acinetobacter baumannii was the most frequent isolated Gram-negative bacteria (19.3%), followed by Klebsiella pneumoniae (17.5%), Pseudomonas aeruginosa (15.8%), and Achromobacter denitrificans (12.3%). A. baumannii exhibited <70% sensitivity to aminoglycoside and carbapenem antibiotics and 100% resistance to third-generation cephalosporins. The most abundant Gram-positive bacteria was Staphylococcus aureus (17.5%), followed by S. haemolyticus (10.5%) and S. epidermidis (3.5%). All S. aureus were sensitive to linezolid, tigecycline, vancomycin, and macrolide antibiotics (azithromycin, clarithromycin, clindamycin, and erythromycin), whereas 50% were sensitive to some beta-lactams. However, 50% of S. aureus were methicillin resistant S. aureus (MRSA). Given the magnitude of multi-drug resistance, an empiric antimicrobial therapy in particular to specific settings and implementation of antibiotic stewardship programs are crucial.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Distribution and antibacterial susceptibility pattern of isolated bacteria from endotracheal aspirates among ventilator-assisted pneumonia patients in Indonesia

Andayani

Mahdani

Nisyra

et al. 2023

Narra J

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“…Antibiotik karbapenem diidentifikasi sebagai antibiotik yang banyak digunakan dalam terapi infeksi yang disebabkan oleh bakteri Gram negatif sehingga memunculkan carbapenemase-mediated multidrug resistant (MDR) yaitu kondisi ketika antibiotik dari golongan ini tidak dapat menghambat pertumbuhan bakteri K. pneumoniae. Oleh karena itu, saat ini dibutuhkan adanya terapi empirik yang lebih optimal terhadap bakteri K. pneumoniae (Salukanan et al, 2018).…”

Section: Pendahuluanunclassified

“…Hasil penelitian lainnya menjelaskan bahwa bakteri K. pneumoniae menempati urutan ketiga sebagai penyebab infeksi pneumonia di ruang ICU RSUP Dr. Hasan Sadikin Bandung pada periode Januari-Desember 2017 (Salukanan et al, 2018).…”

Section: Pendahuluanunclassified

Pembuatan Sediaan Gel Arang Tempurung Kelapa Dan Uji Daya Hambat Terhadap Bakteri Klebsiella pneumoniae

Kamalah,

Kurniawan,

Mulyanto

et al. 2023

Borneo J Med Lab Tech

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Klebsiella pneumoniae is a gram-negative rod-shaped bacterium that is a member of the Enterobacteriaceae group of bacteria and is pathogenic and can infect humans. Currently, many K. pneumoniae bacteria are resistant to antibiotics, giving rise to new problems in the health sector that must be addressed immediately by utilizing biodiversity in the form of medicinal plants such as coconut trees, which can produce coconut shells that can be made into charcoal. The results of the phytochemical analysis show that coconut shell charcoal contains many active compounds that have been used in the cosmetic and health industries. The purpose of this study was to obtain an optimal and effective coconut shell charcoal extract gel formula for inhibiting the growth of K. pneumoniae bacteria. This study included a true experimental post-only control group with different gel concentration groups, namely 3%, 6%, and 9%. The optimal formulation of coconut shell charcoal extract gel is a gel with a concentration of 9%, and the results of the one-way ANOVA statistical analysis show that the treatment of the inhibition test on K. pneumoniae bacteria from gels with different concentrations shows that there is a mean difference in the area of the inhibition zone with a significant value of 0.033 (p<0.05). The results of the LSD post-hoc test showed that several treatment groups had significant values (p <0.05). Based on the results of the study, it can be concluded that the optimal formulation of shell charcoal extract gel is a gel with a concentration of 9%, while the most effective gel for inhibiting the growth of K. pneumoniae bacteria is a gel with a concentration of 3%.

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Pola Pneumonia Nosokomial di Unit Perawatan Intensif Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung Periode Januari–Desember 2017

Cited by 2 publications

References 17 publications

Distribution and antibacterial susceptibility pattern of isolated bacteria from endotracheal aspirates among ventilator-assisted pneumonia patients in Indonesia

Distribution and antibacterial susceptibility pattern of isolated bacteria from endotracheal aspirates among ventilator-assisted pneumonia patients in Indonesia

Pembuatan Sediaan Gel Arang Tempurung Kelapa Dan Uji Daya Hambat Terhadap Bakteri Klebsiella pneumoniae

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