This paper examines the evolving threat of Chemical, Biological, Radiological, and Nuclear(CBRN) materials in terrorism, focusing on their potential use by terrorist organizations andchallenges in detection and prevention. It outlines various CBRN materials, including chemicalagents like nerve and blister agents, biological pathogens such as anthrax, radiological sources likecesium-137, and nuclear materials. Historical case studies, like the 1995 Tokyo subway sarin attackand the 2001 anthrax letters, illustrate their devastating potential.The Ukraine conflict is used as a case study to highlight increased CBRN risks in war-tornenvironments. Scenarios involving nuclear power plants or chemical facilities underscore the needfor stringent security measures and international cooperation.Technological advancements in detection and response, such as wireless sensor networks, portabledetection devices, and advanced decontamination solutions, are crucial. Public awareness andpreparedness, through education and training programs for first responders, enhance communityresilience and readiness.In conclusion, addressing CBRN terrorism requires a coordinated approach, including internationalcooperation, stringent regulations, technological advancements and public education.