Polarity control of DNA adsorption enabling the surface functionalization of CuO nanozymes for targeted tumor therapy

Abstract

A di-block DNA was designed to surface functionalize CuO nanozyme with high biological stability and targetability for nano-catalytic tumor therapy.

Effect of Numbers of Turns of High‐Pressure Torsion on the Development of Exceptional Ductility in Pure Magnesium

“…It is important to note that exceptional ductility was reported in all the reports from which data were included in Figure . These exceptional ductilities include deformation in compression without failure up to ≈40% and ≈80% and elongations in tension up to ≈230% and ≈360% . The present results confirm this trend of exceptional ductility and elongations over 300% were observed in the material processed to 1/2 turn and to 2 turns and tested in tension at 10 —5 s −1 .…”

“…In order to evaluate the effectiveness of these parameters, the strain rates in the current experiments were normalised by the effect of temperature and grain size by considering 75 kJ mol −1 for the activation energy for diffusion and an inverse grain size exponent of 2.5, and these data were then plotted as a function of the flow stress normalised by the shear modulus in Figure . Data from other reports including using different mechanical testing, different grain sizes and different testing temperature, are also presented in Figure for comparison. It is worth noting that the grain size, d , in the present experiments was determined considering a relationship of d = 1.74 × L , where L is the average linear intercept length.…”

“…Strain rate normalised by the grain size and temperature and plotted as a function of the flow stress normalised by the shear modulus .…”

“…Thus, an early report documented unusual high elongations in pure magnesium with a grain size of ≈2 μm . Recently, multiple research groups reported exceptional ductilities in pure magnesium with grain sizes smaller than 3 μm including a maximum elongation of ≈360% in tension at room temperature . Elongations over 200% were also reported in an AZ31 alloy tested in tension at 373 K .…”

Chemodynamic nanomaterials for cancer theranostics

“…Fenton and Fenton-like reactions triggered by iron or other metal ions exhibit the ability to generate abundant •OH by decomposing the endogenous H 2 O 2 in cancer cells [ 40 , 41 ]. Therefore, Fenton and Fenton-like reactions can be used to treat cancer by in-situ production of abundant ROS to kill cancer cells directly [ 42 ], but first, the selection of the catalyst is pivotal [ 43 ]. Several nanomaterials can efficiently trigger Fenton and Fenton-like reactions, due to their high catalytic efficiency and excellent biocompatibility; these include iron-based nanomaterials, other metal-based nanomaterials (including Mn 2+ , Cu 2+ , and Mo 3+ , etc.…”