Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats

Xu, Zhenghao; Wang, Yi; Jin, Miaomiao; Yue, Jiaxing; Xu, Cenglin; Ying, Xiaoying; Wu, Dang; Zhang, Shihong; Chen, Zhong

doi:10.1016/j.brs.2012.04.010

Cited by 23 publications

(19 citation statements)

References 54 publications

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“…The central role of the DG in HPD origin was confirmed in a recent study 27 using optogenetics in the kainate model of epilepsy. From this computational model, we could predict the optimal stimulation polarity (anodal vs. cathodal, which is a critical issue in transcranial stimulation research 28, 29 ) to reduce HPD rate and duration. Model predictions indicated that 1) HPD occurrence and duration decreased only in the cathodal stimulation condition (as opposed to anodal stimulation), and that 2) this effect is mainly mediated by the depolarization of slow, dendritic-targeting inhibitory interneurons.…”

Section: Introductionmentioning

confidence: 99%

Model-guided control of hippocampal discharges by local direct current stimulation

Mina¹,

Modolo²,

Recher³

et al. 2017

Sci Rep

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Neurostimulation is an emerging treatment for drug-resistant epilepsies when surgery is contraindicated. Recent clinical results demonstrate significant seizure frequency reduction in epileptic patients, however the mechanisms underlying this therapeutic effect are largely unknown. This study aimed at gaining insights into local direct current stimulation (LDCS) effects on hyperexcitable tissue, by i) analyzing the impact of electrical currents locally applied on epileptogenic brain regions, and ii) characterizing currents achieving an "anti-epileptic" effect (excitability reduction). First, a neural mass model of hippocampal circuits was extended to accurately reproduce the features of hippocampal paroxysmal discharges (HPD) observed in a mouse model of epilepsy. Second, model predictions regarding current intensity and stimulation polarity were confronted to in vivo mice recordings during LDCS (n = 8). The neural mass model was able to generate realistic hippocampal discharges. Simulation of LDCS in the model pointed at a significant decrease of simulated HPD (in duration and occurrence rate, not in amplitude) for cathodal stimulation, which was successfully verified experimentally in epileptic mice. Despite the simplicity of our stimulation protocol, these results contribute to a better understanding of clinical benefits observed in epileptic patients with implanted neurostimulators. Our results also provide further support for model-guided design of neuromodulation therapy.

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Section: Introductionmentioning

confidence: 99%

Model-guided control of hippocampal discharges by local direct current stimulation

Mina¹,

Modolo²,

Recher³

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The analysis of the EEG background activity showed that the delta power increased during amygdala kindling acquisition, as previously reported [32,33] , which is considered an EEG marker of the severity of seizures [34,35] . Both the amygdala and the GPe in the control and HFS groups exhibited an incensement in delta power, especially in the GS state (P<0.01, compared with baseline).…”

Section: Effects Of Lfs and Hfs On Eeg Background Activity During Kinmentioning

confidence: 66%

“…The power spectral densities of the digitized waveforms were derived using the fast Fourier transform algorithm of the Neuroscan EEG analysis software package, as previously reported [32] , and the EEG power was then calculated.…”

Section: Eeg Background Activity Analysismentioning

confidence: 99%

Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats

Cao¹,

Kuang

Liu

et al. 2015

Acta Pharmacol Sin

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“…1C), EEG recordings in rats aged around P35 were performed for 5 consecutive days around P35 (P33-37), P45 (P43-47), and P60 (P58-62), at least 15 min each day. EEG was recorded as described previously [19] . Raw …”

Section: Eeg Recording In Vivomentioning

confidence: 99%

Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats

et al. 2015

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Prospective and experimental studies have shown that individuals with early-life complex/prolonged febrile seizures (FSs) have a high incidence of temporal lobe epilepsy during adulthood, revealing a close relationship between FSs and epilepsy. However, little is known about how epileptogenesis develops after FSs. The present study was designed to investigate acquired seizure susceptibility and analyze local field potentials during the latent period after FSs. We found that the seizure susceptibility decreased in 35-day-old (P35) FS rats but increased in P60 FS rats. Consistently, hippocampal electroencephalogram (EEG) power in every band was decreased at P35 but increased at P60 in FS rats. Our results provide direct evidence for hypoactivity but not hyperactivity during the early phase of the latent period, displaying a broad decrease in hippocampal rhythms. These characteristic EEG changes can be a useful biomarker for the early diagnosis of epileptogenesis induced by FSs.

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Polarity-dependent effect of low-frequency stimulation on amygdaloid kindling in rats

Cited by 23 publications

References 54 publications

Model-guided control of hippocampal discharges by local direct current stimulation

Model-guided control of hippocampal discharges by local direct current stimulation

Low-frequency stimulation of the external globus palladium produces anti-epileptogenic and anti-ictogenic actions in rats

Early hypoactivity of hippocampal rhythms during epileptogenesis after prolonged febrile seizures in freely-moving rats

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